نتایج جستجو برای: toxicological assessment
تعداد نتایج: 568515 فیلتر نتایج به سال:
BACKGROUND In support of the Integrated Risk Information System (IRIS), the U.S. Environmental Protection Agency (EPA) completed a toxicological review of trichloroethylene (TCE) in September 2011, which was the result of an effort spanning > 20 years. OBJECTIVES We summarized the key findings and scientific issues regarding the human health effects of TCE in the U.S. EPA's toxicological revi...
Validation has become a primary driver of the evolution of toxicological methods. Agreement at OECD level currently requires validation of new approaches for consideration in test guideline development. Several examples of this exist. However, the toxicology in the 21(st) century movement, prompted by the 2007 NRC/NAS vision document, might lead to a revolutionary change in the toxicological to...
The emerging transdisciplinary field of Toxicogenomics aims to study the cell response to a given toxicant at the genome, transcriptome, proteome, and metabolome levels. This approach is expected to provide earlier and more sensitive biomarkers of toxicological responses and help in the delineation of regulatory risk assessment. The use of model organisms to gather such genomic information, thr...
Food preferably has to be tasteful, healthy, attractive, and affordable, but should above all be safe. The safety of our daily food nowadays is at a reasonable level, but is far from obvious. With a certain frequency, food safety incidents come up, and the increasing complexity and globalization of our food production networks contribute to an easy outgrow of such incidents to international cri...
Interest is increasing in the development of non-animal methods for toxicological evaluations. These methods are however, particularly challenging for complex toxicological endpoints such as repeated dose toxicity. European Legislation, e.g., the European Union's Cosmetic Directive and REACH, demands the use of alternative methods. Frameworks, such as the Read-across Assessment Framework or the...
since its introduction in 1959, translation quality assessment (tqa) has been among the most addressed research topics in translation studies. during recent years, there has been a crucial increase on the study of tqa. various methods have come on scene. although these methods are based on scientific theories, most of them have remained at the level of theory. juliane house’s model is among tho...
9. REFERENCES Abu-Hilal AH, Khordagui HK. 1993. Assessment of tar pollution on the United Arab Emirates beaches. Environ Int 19:589-596. ACGIH. 1986. Documentation of the threshold limit values and biological exposure indices. American Conference of Governmental Industrial Hygienists, Cincinnati, OH. ACGIH. 1992. Threshold limit values for chemical substances and physical agents and biological ...
CHATURVEDI AK, CRAFT KJ, CANFIELD DV, WHINNERY JE. Toxicological findings from 1587 civil aviation accident pilot fatalities, 1999–2003. Aviat Space Environ Med 2005; 76:1145–50. Introduction: The prevalence of drug and ethanol use in aviation is monitored by the Federal Aviation Administration (FAA). Under such monitoring, toxicological studies for the 1989–1993 and 1994–1998 periods indicated...
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