BACKGROUND Early stage gastric cancer diagnosis has ensued different approaches in resection strategies. In order to increase the proportion of cases which have undergone radical resection or have reduced the recurrence rate, different pre-operative treatments have introduced. Here, we have verified an active preoperative chemotherapeutic regimen in locally advanced gastric cancer patients. M...

M plant pathogens secrete toxins that disable their host (1). Some of these have general phytotoxic properties and are active toward a broad range of plant species. Others are host-selective, affecting only certain plant varieties or genotypes. These host-selective toxins (HSTs) can act as agents of virulence of pathogens to toxinsensitive hosts, so determining host range or specificity (1, 2)....

In silico screening based on the structures of the ligands or of the receptors has become an essential tool to facilitate the drug discovery process but compound collections are needed to carry out such in silico experiments. It has been recognized that absorption, distribution, metabolism, excretion and toxicity (ADME/tox) are key properties that need to be considered early on, even during the...

Background. The adult mammalian retina is an important model in research on the central nervous system. Many experiments require the combined use of genetic manipulation, imaging, and electrophysiological recording, which make it desirable to use an in vitro preparation. Unfortunately, the tissue culture of the adult mammalian retina is difficult, mainly because of the high energy consumption o...

The production of fibrinous exudates may play an important role in determining the outcome of bacterial infection. Although pseudomembrane formation is a characteristic feature of diphtheria, little is known about the fibrinogen (Fbn)-binding properties of Corynebacterium diphtheriae strains and the influence of the gene that codes for diphtheria toxin (tox gene) in this process. In this study ...

and Applied Analysis 3 Lemma 5. The operators S α and A α have the following properties: (i) for any fixed t ≥ 0 and any x ∈ X β , one has the operators S α (t) and A α (t) which are linear and bounded operators; that is, for any x ∈ X β , 󵄩󵄩󵄩󵄩Sα (t) x 󵄩󵄩󵄩󵄩β ≤ M‖x‖β, 󵄩󵄩󵄩󵄩Aα (t) x 󵄩󵄩󵄩󵄩β ≤ M Γ (α) ‖x‖ β ; (12) (ii) the operatorsS α (t) andA α (t) are strongly continuous for all t ≥ 0; (iii) S α (...

In 1951, Freeman made the remarkable discovery that nontoxinogenic Corynebacterium diphtheriae became toxinogenic2 after association with the lytic phage B, previously described by Toshach (1950). From lysates of nontoxinogenic, nonlysogenic C. diphtheriae, Freeman and Morse (1951) established, through the isolation of single cells, lysogenic strains which were toxinogenic. The lysogenic clones...

Dengue fever is still a major threat worldwide, approximately threatening two-fifths of the world's population in tropical and subtropical countries. Nonstructural protein 5 (NS5) methyltransferase enzyme plays a vital role in the process of messenger RNA capping of dengue by transferring methyl groups from S-adenosyl-l-methionine to N7 atom of the guanine bases of RNA and the RNA ribose group ...