Mechanical ventilation in status asthmaticus is associated with a significant mortality and morbidity. To facilitate intermittent positive pressure ventilation (IPPV), we have used continuous IV thiopental (thiopentone) together with traditional ventilatory techniques. With this policy, we were able to achieve rapid correction of arterial blood gas tensions in a group of 20 severe asthmatics re...

Lepidium sativum Linn. has been used in traditional and folklore medicine for the treatment of bronchial asthma, diabetes, local and rheumatic pain. The present study deals with the investigation of the neurobehavioral effects of the total alkaloid from seeds of Lepidium sativum [LSAF].The effect of LSAF on general pharmacology, thiopental induced hypnosis, locomotor activity, motor coordinatio...

The barbiturates tested in this work (barbital, phenobarbital, thiopental and pentobarbital) modify the partition of synaptosomes in a Dextran T500-poly(ethylene glycol) 4000 two-phase system. Under adequate experimental conditions, the drugs increase the partition into the upper phase and this effect appears to be due to an action on the biological material and not on the interface potential o...

We examined the effects of secobarbital and other sedative-hypnotic barbiturates on the neuronal death induced by exposure to excitatory amino acids or deprivation of oxygen or glucose in mouse cortical cell cultures. N-Methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionate, and kainate toxicities were attenuated in a concentration-dependent fashion by high concentrati...

Smith, C. Beebe, C. Eintrei, J. Kang, and Y. Sun. Effects of thiopental anesthesia on local rates of cerebral protein synthesis in rats. Am. J. Physiol. 274 (Endocrinol. Metab. 37): E852–E859, 1998.—We have examined the effects of a surgical level of thiopental anesthesia in adult male rats on local rates of cerebral protein synthesis with the quantitative autoradiographic L-[1-14C]leucine meth...

dermoid cyst is a tumor arises due to embryogenesis impairment. it accounts for less than 0.3 percent of all intracranial masses. a 35 years old man presented with a tonic clonic seizure without any significant past history of seizure. physical examination and imaging propounded epidermoid cyst as diagnosis. the patient had a craniotomy and cyst was totally removed. operative findings and histo...

in a cross section of the patients scheduled for various operations, the plausability of lidocaine as an induction agent is studied and described. the results were dismaying suggesting, henceforth, that as an induction agent, lidocaine altogether fails to accomplish the assignment assigned to this drug.

the technique of intraosseous (io) infusion has been reemerged as an alternative route of intravascular access for the delivery of fluids and some medications. complications of io infusion occur rarely and include fractures and osteomyelitis after long-term use of io access. the purpose of this study was to compare the efficiency of induction of anaesthesia by a standard intravenous route and a...