Cimetidine, an H₂ receptor antagonist used for treatment of gastric ulcers, exerts antiandrogenic and antiangiogenic effects. In the testes cimetidine impairs spermatogenesis, Sertoli cells and peritubular tissue, inducing apoptosis in the myoid cells. Regarding the importance of histamine and androgens for vascular maintenance, the effect of cimetidine on the structural integrity of the testic...

Morphological features of the testicular artery and vein in the spermatic cord of the musk shrew (Suncus murinus) were evaluated by light microscopy, transmission electron microscopy, corrosion cast technique combined with scanning electron microscopy and immunohistochemistry. The vascular architecture in the spermatic cord of the musk shrew was simple. The testicular artery in the musk shrew w...

Proliferating hybrids were formed between rat spermatids and LM(TK~) cl 1 D, an established line of mouse fibroblasts. Spermatids were obtained from dissociated rat seminiferous tubules by differential attachment of testicular somatic cells to culture plates, followed by gravity velocity sedimentation into linear Ficoll gradients. Cells were fused with the aid of Sendai virus and hybrid selecti...

GATA-4 is a highly conserved transcription factor that plays a critical role in regulating embryonic morphogenesis and cellular differentiation. Given the emerging role of GATA-4 in the development and function of murine gonads, we have now studied its role in human testis. We find that GATA-4 is expressed from early human fetal testicular development to adulthood. This transcription factor is ...

Estrogens play important roles in the regulation of testis development and spermatogenesis. Moreover, several evidences suggest that estrogen signaling can be involved in testicular tumorigenesis. The physiological effects of estrogen are mediated by the classical nuclear estrogen receptors ESR1 and 2, which regulate both genomic and rapid signaling events. In the recent years, a member of the ...

Background: Dr. Aladdin’s seven keys herbal mixture is widely used to relieve feverish conditions, and skin rashes especially in measles, chickenpox, viral infections, malaria, diarrhoea, ulcers, bacterial infections other conditions. Objective: The present study examined the testicular effect of Dr Aladdin's on male Wistar rats. Materials methods: A total 20 adult male. rats weighing between 1...

context to review and summarize the literature regarding the current status of postchemotherapy laparoscopic retroperitoneal lymph node dissection (pcl-rplnd) in patients with testicular germ cell tumor. evidence acquisition a comprehensive review of the english literature was performed using the pubmed database using the terms “laparoscopy” or “laparoscopic”, retroperitoneal lymph node dissect...

The distribution of XX and XY cells in XX----XY chimaeric mouse testes was analysed by enzyme marker analysis of separated testicular tissues and by in situ DNA marker analysis of air-dried testicular cells and testis sections. XX cells contributed to the Leydig cells, the peritubular cells and the vascularized connective tissue of the tunica albuginea. The Sertoli cells, on the other hand, app...

The failure of testicular descent or cryptorchidism is the most common defect in newborn boys. The descent of the testes during development is controlled by insulin-like 3 peptide and steroid hormones produced in testicular Leydig cells, as well as by various genetic and developmental factors. While in some cases the association with genetic abnormalities and environmental causes has been shown...

The ultrastructure of testicular cells of adult male African clawed frogs (Xenopus laevis) exposed to either estradiol (0.1 microg/L) or 2-chloro-4-ethylamino-6-isopropyl-amino-s-triazine (atrazine; 10 or 100 microg/L) was examined by electron microscopy and compared to plasma concentrations of the steroid hormones, testosterone (T) and estradiol (E2), testicular aromatase activity and gonad gr...