s of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy. Orlando, FL. Washington, DC, American Society for Microbiology, 1994, p 266 (abstr H76) 148. Masucci G, Wersäll P, Ragnhammar P, Mellstedt H: Granulocytemonocyte-colony-stimulating factor augments the cytotoxic capacity of lymphocytes and monocytes in antibody dependent cellular cytotoxicity. Cancer Immunol Immunoth...

BACKGROUND/AIMS Colony-stimulating factors (CSFs) are well-known hematopoietic growth factors. Although recent studies revealed that CSFs are involved in many inflammatory conditions, the local production of CSFs and its regulation in the kidney is not well elucidated. Therefore, using cultured human proximal tubular epithelial cells (PTEC), we examined the effect of thrombin on CSFs production...

The macrophage-specific colony-stimulating factor 1 (CSF-1 or M-CSF) is required throughout the G1 phase of the cell cycle to regulate both immediate and delayed early responses necessary for cell proliferation. These are triggered by the binding of the growth factor to the colony-stimulating factor 1 receptor and the activation of its intrinsic tyrosine-specific protein kinase. Phosphorylation...

s of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy. Orlando, FL. Washington, DC, American Society for Microbiology, 1994, p 266 (abstr H76) 148. Masucci G, Wersäll P, Ragnhammar P, Mellstedt H: Granulocytemonocyte-colony-stimulating factor augments the cytotoxic capacity of lymphocytes and monocytes in antibody dependent cellular cytotoxicity. Cancer Immunol Immunoth...

BACKGROUND Information about the long-term follow-up and safety of granulocyte colony-stimulating factor administration to healthy donors is limited. The aims of this study were to analyze the side effects of granulocyte colony-stimulating factor administration in donors included in a Spanish Registry of hematopoietic stem cell donors and to determine the long-term outcome of these donors. DE...

background: over the past decade, survival from advanced colorectal cancer is increasing. therefore patients have more exposure to chemotherapy and related toxicities. this study determines how hematologic toxicity patterns affect therapy and care. methods: from april 2010 to march 2013, we enrolled 127 patients with stages iib to iv colorectal cancer. patients underwent complete blood count mo...

A b stract P urp ose: T o imp rov e the ef f ectiv enes s of g ranu locy te colony -s timu lating f actor ( G -C SF ) treatment in hig h-ris k neu trop enic p atients . E x p erimental D esign: W e s tu dy G -C SF ef f ects on chemotherap y -indu ced neu trop enia b y ex p anding a s imp le mathematical model of neu trop hil dy namics in the b lood. T he f inal model is f itted and v alidated u...

The granulocyte colony-stimulating factor (G-CSF) plays an important role in normal granulopoiesis. Its functions are mediated by specific receptors on the surface of responsive cells and, upon ligand binding, several cytoplasmic tyrosine kinases are activated. The cytoplasmic region proximal to the membrane of the G-CSF receptor (G-CSF-R) transduces proliferative and survival signals, whereas ...

The effects of media conditioned by leukemic cells from 11 acute myeloblastic leukemia patients on the growth of autologous blast progenitors were studied. First, it was shown that T-cell-depleted leukemic cells from some patients release high levels of colony-stimulating activity into the culture medium, whereas following further depletion of phagocytic cells, the levels of colony-stimulating ...