Dual-probe microdialysis (with HPLC and electrochemical detection) in freely moving rats and single-unit recording in anesthetized rats were used to study the extent to which impulse flow through the ventral tegmental area (VTA) contributes to elevations in nucleus accumbens (NAS) dopamine (DA) evoked by stimulation of the ventral subiculum (VS). During perfusion of artificial extracellular flu...

We report the first use of a convolutional neural network for terahertz (THz) imaging combined with single-pixel camera to achieve high quality hyperspectral THz 10× faster than current commercial systems, potential only limited by noise. Imaging spatial light modulator (SLM) relies on projecting set patterns onto an object and recording transmission detector, optical delay unit (ODU) is used o...

Compound muscle action potential (CMAP) and motor unit number estimation (MUNE) are electrophysiological techniques that can be used to monitor the functional status of a motor unit pool in vivo. These measures can provide insight into the normal development and degeneration of the neuromuscular system. These measures have clear translational potential because they are routinely applied in diag...

To investigate how neuronal activity in the prefrontal cortex changes in an animal model of schizophrenia, we recorded single unit activity in the medial prefrontal cortex of urethane-anesthetized and awake rats following methamphetamine (MA) administration. Systemic MA injection (4 mg/kg, IP) induced inconsistent changes, that is, both enhancement and reduction, in unit discharge rate, with a ...

A beginning has recently been made in recording single neurone activity from animals with chronically implanted electrodes (Hubel, 1957a; Gusel'nikov, 1957; Ricci, Doane & Jasper, 1957; Strumwasser, 1958). These methods eliminate anaesthetics, paralysing drugs, brain-stem lesions, and other acute experimental procedures. They make it possible to record electrical events in the higher central ne...

Introduction: Although formalin-induced activity in primary afferent fibers and spinal dorsal ‎horn is well described, the midbrain neural basis underlying each phase of behavior in ‎formalin test has not been clarified. The present study was designed to investigate the nucleus ‎cuneiformis (CnF)‎‏ ‏neuronal responses during two phases after subcutaneous injection of ‎formalin into the hind paw...

Parallel recording of neuronal activity in the behaving animal is a prerequisite for our understanding of neuronal representation and storage of information. Here we describe the development of micro-machined silicon microelectrode arrays for unit and local field recordings. The two-dimensional probes with 96 or 64 recording sites provided high-density recording of unit and field activity with ...

The single-neuron doctrine is reexamined, and the search for causal links between single units and sensation reviewed. Although several decades of single-unit recording have been very successful in elucidating physiological mechanisms, linking signals from a single cell and perception has progressed at a slower rate. Nevertheless, analysing the activity of single neurons has achieved significan...