Protein homology detection is an important issue in comparative genomics. Because of the exponential growth of sequence databases, fast and efficient homology detection tools are urgently needed. Currently, for homology detection, sequence comparison methods using local alignment such as BLAST are generally used as they give a reasonable measure for sequence similarity. However, these methods h...

The prediction of three-dimensional protein structures from onedimensional amino acid sequence information is an important and interesting problem, as much can be learned about a protein’s function from the way that it is folded. There are many different ways to approach this problem, but they all tend to fall into three basic categories: homology modeling, fold recognition, and ab initio predi...

Directed evolution has become a powerful tool for developing enzyme and whole cell based biocatalysts. Significant recent advances include the creation of novel enzyme functions and the development of several new efficient directed evolution methods. The combination of directed evolution and rational design promises to accelerate the development of biocatalysts for applications in the pharmaceu...