Chaperone t herapy i s a n ew co ncept o f m olecular t herapeutic approach m ainly d eveloped f or l ysosomal d iseases, b ased o n a p aradoxical molecular interaction involving a mutant en zyme and its competitive in hibitor as an intracellular en hancer ( chaperone). T he misfolded mutant pr otein is transported safely to the lysosome as a co mplex with a specific chaperone. The enzyme act ...

It was assumed that the degraded image H was of the form H= W*S, where W is the original image, S is the point spread function, and * denotes the operation of convolution. It was also assumed that W, S, and H are discrete probability-frequency functions, not necessarily normalized. That is, the numerical value of a point of W, S, or H is considered as a measure of the frequency of the occurrenc...

Rapid deforestation i n Mexico, when cozrpled w i t h poor access to current and consistent ecological information across the col lntry underscores the need for a n ecological classification sys t em that can be readily updated and n e w data beconze available. In this s tudy , regiorzal vegetation resources i n Mexico were evaluated us ing remotely sensed information. Mtllt i temporal Global V...

u n d o u b t e d l y, i n t h e l a s t d e c a d e s, t h e a s s e t p r i c i n g m o d e l i so n e o f m o s t i m p o r t a n t a n d, a t t h e s a m e t i m e, a t t r a c t i v e, f i n a n c e a r e a s. c a p m h a s b e e n t h e d o m i n a n t m o d e l i n t h i s s e c t i o n f o r m o r e t h a n 40 y e a r s. o n e r e a s o n i s i t s s t r o n g b a s e, w h i c h h a s b...

Fig. 3. Step Recovery Diodes in glass and ceramic packages. Ceramic pack age is designed to be especially useful u-ith coaxial structures but can also be used in other ways as in Fig. 8. h p ' s a f f i l i a t e , h p a s s o c i a t e s , w a s e s t a b l i s h e d f o u r y e a r s a g o t o p e r f o r m r e s e a r c h , d e v e l o p m e n t a n d m a n u f a c t u r i n g i n t h e s e ...

The first phase of this s tudy was the production of contemporary straightbred (SB) and reciprocal crossbred (F 1 ) bulls by mating Angus (A) bulls to A and Santa Gertrudis (SG) cows and SG bulls to SG and A cows. Of the bulls produced during the 4-yr period, those used for breeding included 15 A, 15 SG, 8 A x SG and 8 SG x A. For 205-d weight and weight /day of age (W/DA) postweaning, A X SG h...

EDITOR – We re ad w ith great inte re st the publication from Pé re z-Arellano and colle ague s. The aim of this study w as to evaluate the partic ipation of PAF in ex trinsic allergic alveolitis. We w ould like to bring to your attention the fac t that w e published a s imilar study a few years ago. Both studies show striking methodological similarities, namely the use of the same antigen to i...

Father Theodore Hesburgh, president emeritus, has become a m em ber o f a twelve person advisory council for First AID, a fund ra is ing pro ject to benefit the N a tio n a l A sso c ia tio n o f People w ith AIDS (NAPWA). F irs t AID w ill consist mainly of a nationwide telephone auc­ tion in November. The auction, conducted v ia a 900 number, w ill include one-of-a-kind ex­ periences such as ...

Q: H ow long have y o u been dean o f students, a n d w ha t is the role o f the dean a t Sa in t M ary’s? A: My title really isn't clean of stu ­ dents, it's dean of student affairs. I cam e to Saint Mary’s in August of 1976, so this is my fifth year. Dean of Student Affairs is a senior office posi­ tion so that I report directly to the president. There are eight different departm ents and eac...

Ethanol-induced damage is largely attributed to its toxic metabolite, acetaldehyde. Clearance of acetaldehyde is achieved by its oxidation, primarily catalyzed by the mitochondrial class II aldehyde dehydrogenase (ALDH2). ALDH1B1 is another mitochondrial A LDH t hat s hares 75% peptide sequence h omology w ith A LDH2. R ecent p opulation studies in C aucasians suggest a r ole f or ALDH1B1 in e ...