نتایج جستجو برای: s adjuvant

تعداد نتایج: 752801  

Journal: :The Journal of Experimental Medicine 1995
J G Conway J A Wakefield R H Brown B E Marron L Sekut S A Stimpson A McElroy J A Menius J J Jeffreys R L Clark

Considerable evidence has associated the expression of matrix metalloproteinases (MMPs) with the degradation of cartilage and bone in chronic conditions such as arthritis. Direct evaluation of MMPs' role in vivo has awaited the development of MMP inhibitors with appropriate pharmacological properties. We have identified butanediamide, N4-hydroxy-2-(2-methylpropyl)-N1-[2-[[2-(morpholinyl)ethyl]-...

2013
Han Zhang Peter T Dziegielewski Vince L Biron Jacek Szudek Khaled H Al-Qahatani Daniel A O’Connell Jeffrey R Harris Hadi Seikaly

BACKGROUND The oral cavity is the most common site for head and neck squamous cell carcinoma. Treatment of advanced stage oral cavity squamous cell carcinoma (OCSCC) has classically involved surgical resection with postoperative adjuvant radiotherapy (S-RT).Despite this aggressive dual modality therapy, the disease outcomes have remained poor. The treatment options expanded in 2004 when two int...

Maryam Eskandari Mohsen Tafaghodi,

Objective(s) The immunoadjuvant potential of cross-linked dextran microspheres (CDM) as absorption enhancer and Quillaja saponins (QS) as immunomodulator adjuvant was evaluated. Materials and Methods CDM loaded or tetanus-mixed toxoid (TT) or Quillaja saponin (QS) were nasally administered to rabbits in dry powder form, three times in 2 weeks interval and serum IgG and nasal lavage sIgA tite...

Objective(s): Brucellosis is a common infectious disease among animals and humans. While subunit vaccines could be used as an efficient strategy against pathogens, they usually seem to be less immunogenic than live or killed vaccines. However, the use of a suitable adjuvant accompanied by subunit vaccines can be a good alternative to enhance the immune response.Materials and Methods: To find a ...

2015
Osamu Itano Naokazu Chiba Masatsugu Ishii Masahiro Shinoda Minoru Kitago Yuta Abe Taizo Hibi Hiroshi Yagi Motohide Shimazu Yuko Kitagawa

Objective: We compared the influence of postoperative adjuvant chemotherapy with oral anticancer drugs (S-1 or uracil-tegafur [UFT]) and the influence of surgery alone on overall survival (OS) and disease-free survival (DFS) in patients with biliary tract cancer. Methods: This retrospective study included 108 patients with gallbladder cancer (n=22) or bile duct cancer (n=86), who underwent cura...

1962
Aalzen de Haan

This paper reports on a novel immunoadjuvant activity of liposomes. An influenza subunit preparation, containing the isolated viral surface antigens, was incorporated a liposomal formulation. Administration of this vaccine to mice via the intranasal (i.n.) route resulted in a stimulated serum IgG response relative to the response to i.n. immunization with the antigen alone. In addition, the lip...

Journal: :iranian journal of basic medical sciences 0
mohsen tafaghodi school of pharmacy, mashhad university of medical sciences, mashhad, iran nanotechnology research center, mashhad university of medical sciences, mashhad, iran maryam eskandari school of pharmacy, mashhad university of medical sciences, mashhad, iran

objective(s) the immunoadjuvant potential of cross-linked dextran microspheres (cdm) as absorption enhancer and quillaja saponins (qs) as immunomodulator adjuvant was evaluated. materials and methods cdm loaded or tetanus-mixed toxoid (tt) or quillaja saponin (qs) were nasally administered to rabbits in dry powder form, three times in 2 weeks interval and serum igg and nasal lavage siga titers ...

2017
Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liu Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji

BACKGROUND The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer. Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision. METHODS We have commenced a randomized phase III trial in December 2016...

2013
Thomas F. Kresina G. Richard

This study presents the characterization of an experimental immunotherapeutic approach for schistosomiasis utilizing antiidiotypic antibodies. Antiidiotype (31-3B6) was generated in rabbits using a protective murine monoclonal antibody 31-3B6 which recognizes a 68,000-D molecular mass glycoprotein present in extracts of Schistosomiasis mansoni adult worm homogenetics. Immunization of mice with ...

Journal: :Annals of pulmonology 2022

Summary Ketamine is a racemic mixture of two enantiomers, R- and S-ketamine [1]. The primarily used as anaesthestic agent. In low or sub anaesthetic doses, ketamine has potent analgesic properties, it been effectively either primary adjuvant in varieties pain syndromes burn dressings children [2]. this case report, we illustrate the effectiveness oral controlling during wound dressing an adult ...

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