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background: embryonic stem cells (esc) are pluripotent cells which have been used as a model to study the mechanism that control the embryogenesis and early mammalian development in vitro. the aim of this study was to isolate and produce embryonic stem cells from late blastocyst stage embryos in mice. materials and methods: blastocyst stage embryos from pregnant nmri mice were obtained and cult...

previous studies have demonstrated the potential of monotherapy with either mesenchymal stem cells (mscs) or estrogen in autoimmune and cuprizone models of multiple sclerosis (ms). the aim of this study was to examine the effects of co-administration of 17β-estradiol (e2) and adipose-derived mesenchymal stem cells (adscs) on remyelination of corpus callosum axons in a cuprizone model of ms. for...

background: human umbilical cord blood (hucb) is an acceptable and readily accessible source of stem cells. there is an ongoing interest in cord blood stem cell therapies; however, little is known about the possible unfavorable effects of laboratory modifications on the isolated hucb cells. the involvement of mirnas in several biological processes has been shown. the aim of this study was to ev...

background: the mechanism of cadmium induced osteoporosis is not well understood, so in this study, we examined the toxicity of bone marrow mesenchymal stem cell (mscs) following treatment of rats with cdcl2 in drinking water, to revile the effect of this chemical on differentiation potential of mscs. methods: at the end of third passage, mscs were grown in the osteogenic medium for 21 days. to...

objective(s): adipose derived stem cells (adscs) can be engineered to express bone specific markers. the aim of this study is to evaluate repairing tibia in animal model with differentiated osteoblasts from autologous adscs in alginate scaffold. materials and methods: in this study, 6 canine’s adscs were encapsulated in alginate and differentiated into osteoblasts. alkaline phosphatase assay (a...

objective(s):cardiomyocytes have small potentials for renovation and proliferation in adult life. the most challenging goal in the field of cardiovascular tissue engineering is the creation of an engineered heart muscle. tissue engineering with a combination of stem cells and nanofibrous scaffolds has attracted interest with regard to cardiomyocyte creation applications. human adipose-derived s...

objective(s): in the past few decades, variety of foetal, embryonic and adult stem and progenitor cells have been tried with conflicting outcome for cell therapy of central nervous system injury and diseases. cellular characteristics and functional plasticity of globose basal stem cells (gbcs) residing in the olfactory epithelium of rat olfactory mucosa have not been studied in the past by the ...

objective(s):bone marrow-derived mesenchymal stem cells (bmscs) have attracted significant interest to treat asthma and its complication. in this study, the effects of bmscs on lung pathology and inflammation in an ovalbumin-induced asthma model in mouse were examined. materials and methods:balb/c mice were divided into three groups: control group (animals were not sensitized), asthma group (an...

introduction: brain injury is an important cause of morbidity and mortality worldwide and so far, there has been no absolute treatment for the damaged brain tissue. using human stem cells with self-assembling scaffolds can be a promising method for treatment of traumatic brain injury. materials and methods: human meningioma stem cells were isolated, cultured and then expanded into in vitro cond...