Lee, H. Thomas, and Charles W. Emala. Protective effects of renal ischemic preconditioning and adenosine pretreatment: role of A1 and A3 receptors. Am. J. Physiol. Renal Physiol. 278: F380–F387, 2000.—Renal ischemia and reperfusion during aortic and renal transplant surgery result in ischemic-reperfusion injury. Ischemic preconditioning and adenosine infusion before ischemia protect against isc...

BACKGROUND Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury and often leads to multiorgan dysfunction and systemic inflammation. Volatile anesthetics have potent antiinflammatory effects. We aimed to determine whether the representative volatile anesthetic isoflurane protects against acute kidney injury-induced liver and intestinal injury and to determine the mech...

BACKGROUND Although nephron-sparing surgery has been reported not to affect total renal function, it is a non-negligible fact that functional damage of the operated kidney usually results, for various reasons. This study aimed to explore the effects of preoperative baseline characteristics, tumor characteristics, and function protection methods on postoperative renal damage. METHODS This stud...

a. At 5 years (median 34 months), correction of renal artery stenosis (RAS), by balloon angioplasty with or without stenting (no distal protection) has no beneficial effect on blood pressure (BP) compared with medical therapy and is associated with an adverse event rate of 10–25%. (Level I Evidence) b. At 5 years (median 34 months), correction of RAS, by balloon angioplasty with or without sten...

Polyaspartic Acid (PAA) protects the kidney from experimental gentamicin nephrotoxicity despite large increases in renal cortical gentamicin content. In these experiments, prominent cytoplasmic vacuoles were noted in all animals that received PAA with or without gentamicin. The present study showed that there were no renal structural or functional consequences of PAA given alone or with gentami...

a. At 5 years (median 34 months), correction of renal artery stenosis (RAS), by balloon angioplasty with or without stenting (no distal protection) has no beneficial effect on blood pressure (BP) compared with medical therapy and is associated with an adverse event rate of 10–25%. (Level I Evidence) b. At 5 years (median 34 months), correction of RAS, by balloon angioplasty with or without sten...

In the pediatric patient, traumatic injury is the leading cause of death and blunt trauma is themost commonmechanism of injury. Renal injuries account for 8 to 12% of pediatric blunt abdominal injuries. Children, more so than adults, are prone to sustain major renal injury due to blunt trauma given the relatively large size of pediatric kidneys and decreased protection in children.1–3 The prima...

Boon AC, Bulmer AC, Coombes JS, Fassett RG. Circulating bilirubin and defense against kidney disease and cardiovascular mortality: mechanisms contributing to protection in clinical investigations. Am J Physiol Renal Physiol 307: F123–F136, 2014. First published April 23, 2014; doi:10.1152/ajprenal.00039.2014.—Unconjugated bilirubin is an endogenous circulating antioxidant, bound to albumin, and...