The vibrational analysis of elastic models suggests that the essential motions of large biomolecular assemblies can be captured efficiently at an intermediate scale without requiring knowledge of the atomic structure. While prior work has established a theoretical foundation for this analysis, we demonstrate here on experimental electron microscopy maps that vibrational modes indeed describe fu...

This paper develops a theoretical model for wrinkling of an elastic film on an elastic–plastic metal layer caused by cyclic temperatures. The film is compressively strained and bonded to the metal layer, which in turn lies on a thick substrate. The thermal expansion mismatch between the metal and the substrate induces a biaxial stress, which is assumed to be large enough to cause the metal to d...

I will discuss two fluid-body interaction problems. The first relates to the experiments of Moret and Zhang (NYU Applied Math Lab, 2008) on a wing with active heaving but passive pitching. The experiments have indicated the existence of a bistable region in flapping frequency where either ”forward” or ”backward” flight may be achieved. I will discuss numerical simulations that are used to bette...

By using single-molecule fluorescence resonance energy transfer (smFRET), we observe the real-time dynamic coupling between the ribosome, labeled at the L1 stalk, and transfer RNA (tRNA). We find that an interaction between the ribosomal L1 stalk and the newly deacylated tRNA is established spontaneously upon peptide bond formation; this event involves coupled movements of the L1 stalk and tRNA...

The mechanism of substrate translocation through the ribosome is central to the rapid and faithful translation of mRNA into proteins. The rate-limiting step in translocation is an unlocking process that includes the formation of an "unlocked" intermediate state, which requires the convergence of large-scale conformational events within the ribosome including tRNA hybrid states formation, closur...

In this article, we examine education policymaking in England during the Covid-19 pandemic, focusing on period from 2020 to 2022. We argue that while obviously damaging materially, economically and psychologically, seemed have provided a rare opportunity for step change, chance recalibrate reconsider values assumed as ‘truths’. However, appears been driven by desire return normal soon possible ...

Since narrative is a foundational framework for the on-going co-evolution of human cognition and culture, the advent of computation as a new medium for representing narratives offers the promise of ratcheting up human understanding and expressive power, just as previous media of representation like language and writing have done. But digital representation often produces artifacts that are stor...

Since narrative is a foundational framework for the on-going co-evolution of human cognition and culture, the advent of computation as a new medium for representing narratives offers the promise of ratcheting up human understanding and expressive power, just as previous media of representation like language and writing have done. But digital representation often produces artifacts that are stor...

Recent single molecule studies have made a significant contribution to the understanding of the molecular mechanism involved in the movement of motor proteins which process DNA and RNA. Measurement of stepsize in two disparate motors, NS3 helicase and ribosome both revealed 3-bp steps, which consist of three hidden substeps. Combined with previous structural studies, NS3 is likely taking a sing...

A decisive step in the biosynthesis of many proteins is their partial or complete translocation across the eukaryotic endoplasmic reticulum membrane or the prokaryotic plasma membrane. Most of these proteins are translocated through a protein-conducting channel that is formed by a conserved, heterotrimeric membrane-protein complex, the Sec61 or SecY complex. Depending on channel binding partner...