We describe an ultramicromethod for determination of uric acid by a manual procedure. Hydrogen peroxide, formed when uric acid is oxidized in the presence of uricase, oxidatively couples two molecules of p-hydroxyphenylacetic acid in the presence of peroxidase to produce a highly fluorescent compound. The specificity of the uricase reaction is retained, and the fluorometry results in a higher s...

5). The hepatoma is one of the most common neo plasms produced by this drug in the rat. The pur poses of the following experiments were to deter mine the carcinogenic activity of 2-acetylarninofluorene in the dog and to discover some of the changes in metabolism produced by the drug, par ticularly those associated with the induction of hepatomas. Changes in liver function and struc ture are rev...