A multifunctional, ubiquitous molecule, adenosine acts at cell-surface G protein-coupled receptors, as well numerous enzymes, including protein kinases and adenylyl cyclase. Extracellular is thought to be produced either by export or metabolism, predominantly through ecto-5’-nucleotidase activity (also producing inorganic phosphate). It inactivated extracellular metabolism via deaminase ammonia...

SRC kinases and PKR are intracellular protein kinases, which play key roles in intracellular viral replication. In this research, the effect of SRC kinase inhibition and PKR activation and inhibition on replication of coxsakievirus (CVB3), an entrovirus of the family picornaviridae – causative agents of fatal myocarditis, was studied. Vero and Hela cells were cultured and infected with CVB3 in ...

A protein kinase domain, a Rhodanase-like and the Tre-2/Bub2/Cdc16 (TBC) domain are all encoded by TBCK gene. By modulating mammalian target of rapamycin (mTOR) signaling pathway, is hypothesized to play role in actin organization, cell growth, proliferation. Has organization cytoskeleton.