Current Biology starts with the following categorical statement: " Compelling arguments eliminate the idea that death is generally programmed by genes for ageing " [1]. The end of the abstract is less categorical: " It is recognized that in exceptional circumstances the possibility exists for selection to favor limiting survival. In acknowledging that at least in theory, aging might occasionall...

Cell DNA Gel (all +40U/mL DNase) Media Culture Time CPA Progression Fig 1I A-amine MCF-10A Aprime-lipid n/a n/a n/a 1) 10A&Aprime A-lipid 2) 10A&A 3) 10A&Aprime Fig 2A-C, 3A, S2D-E A-amine MCF-10A Aprime-lipid 9 mg/mL Matrigel 10A Assay Medium 24 hours 1) 10A&Dprime B-amine MCF-10A Bprime-lipid 2) 10A&Bprime D-amine MCF-10A Dprime-lipid 3) 10A&Aprime Fig 2D-H, S2C A-amine MCF-10A Aprime-lipid 9...

We generalise the well-known notion of programmed grammars without appearance checking by introducing a buffer that could store sequences of rules, thus not necessarily describing the rule to be selected in the very next step, but rather in some future time.

Learning how to control the formation and twoand three-dimensional assembly of molecular scale building blocks into well-defined mesoand macroscopic structures is the essence of nanotechnology and materials chemistry. DNA is arguably one of the most programmable “assemblers” available to the synthetic chemist and materials scientist, yet until recently, it has been an underutilized synthon in m...

Programmed cell death (PCD) of Dictyostelium discoideum cells was triggered precisely and studied quantitatively in an in vitro system involving differentiation without morphogenesis. In temporal succession after the triggering of differentiation, PCD included first an irreversible step leading to the inability to regrow at 8 hours. At 12 hours, massive vacuolisation was best evidenced by confo...

in many models of programmed cell death, the mitochondrial protein aif translocates to the nucleus, where it induces the chromatin condensation and dna degradation. however, today it is well established that this flavoprotein is bifunctional. in addition to its lethal function in the nucleus of dying cells, aif plays a vital bioenergetic role in healthy ones by regulating mainly the activity of...