Prions are ‘‘infectious’’ misfolded protein states that can template their self-perpetuating conformations onto other molecules of the same type. This unusual folding landscape drives a paradigm-shifting mechanism of inheritance based on changes in protein conformation rather than changes in nucleic acid. The first prion discovered, Prion Protein (PrP), is the causal agent of several human neur...

The Gillespie Algorithm is used to simulate a prion model so that the kinetics of the prions may be observed. The model is purely autocatalytic, that is, there is no fusion or fission of the infectious units. There is only conversion of PrP C into prions through a mechanism comprised of attaching PrP C to a PrP Sc p-mer, domain swapping, and splitting. It is well known that any model of an infe...