BACKGROUND Since the late 1980s, there has been evidence of an international trend towards more organised primary care. This has taken a number of forms including the emergence of primary care organisations. Underpinning such developments is an inherent belief in evidence that suggests that well-developed primary care is associated with improved health outcomes and greater cost-effectiveness wi...

A key feature of many adult stem cell lineages is that stem cell daughters destined for differentiation undergo several transit amplifying (TA) divisions before initiating terminal differentiation, allowing few and infrequently dividing stem cells to produce many differentiated progeny. Although the number of progenitor divisions profoundly affects tissue (re)generation, and failure to control ...

Leaf venation patterns vary considerably between species and between leaves within a species. A mechanism based on canalization of auxin transport has been suggested as the means by which plastic yet organized venation patterns are generated. This study assessed the plasticity of Arabidopsis thaliana leaf venation in response to ectopic ground or procambial cell divisions and auxin transport in...

Basic fibroblast growth factor (bFGF) exerts a mitogenic effect on cortical neuroblasts, whereas neurotrophin 3 (NT3) promotes differentiation in these cells. Here we provide evidence that both the mitogenic effect of bFGF and the differentiation-promoting effect of NT3 are linked with modifications of cell cycle kinetics in mouse cortical precursor cells. We adapted an in vitro assay, which ma...

Many real-life problems involve the matching of talented individuals to institutions such as firms, hospitals, or schools, where these institutions are simply treated as individual agents. In this paper, I study many-to-one matching with contracts that incorporates a theory of choice of institutions, which are aggregate actors, composed of divisions that are enjoined by an institutional governa...

An ever-expanding body of empirical research suggests that ethno-religious divisions adversely impact a host of normatively desirable objectives linked to the quality of life in society, implicitly representing a strong challenge to multiculturalist theory and policies. The appropriate conceptualization and measurement of ethno-religious divisions has consequently become the subject of complex ...