The water-soluble gold(III) complex [Au(III)(butyl-C^N)biguanide]Cl (butyl-HC^N = 2-(4-n-butylphenyl)pyridine, BCN) displays cytotoxicity through S-phase cell cycle arrest and endoplasmic reticulum (ER) damage in HeLa cells, and shows a promising anti-angiogenic effect at sub-cytotoxic concentrations.

Acute pancreatitis frequently presents with abdomen pain but may presents with various skin manifestations as rash and rarely, pancreatic panniculitis. Metformin, one of the most effective and valuable oral hypoglycemic agents in the biguanide class was linked to acute pancreatitis in few cases. Here, we report a case of metformin induce acute pancreatitis in young healthy man with normal renal...

This paper presents the results of a comparative analysis preparations used for reducing risk associated with biological agents, which may cause diseases in humans, as well destruction materials and biofouling different equipment. In course selecting disinfectants it is possible necessary to combine such actual requirements high level ecological compatibility economical feasibility. Preparation...

To the Editor: In recent months an increasing number of patients have been referred to us by doctors from outside with a standard note: ' breathlessness ... tiredness anaemia (4 8 g/IOO mJ) blood transfusion given .. Hb now 12 g/IOO ml please see and treat'. Many of these patients have required urgent blood-leiting and dialysis for iatrogenic pulmonary oedema and renal failure. Few doctors real...

The results of a study the wound healing activity composition based on hydrogel polyhexamethylene guanidine hydrochloride and Bergenia crassifolia extract, under conditions modeling thermal burns in laboratory animals (rats), are presented. It was found that affects change summary antioxidant leukocyte towards normalization these indicators. Morphological analysis slices showed that, influence ...

Electrospun poly (vinyl alcohol) [PVA] nanowebs functionalized with a commercially available microbiocidal solution ReputexTM 20 were prepared. The active ingredient of ReputexTM 20 is polyhexamethylene biguanides, a safe antiseptic. Fourier Transform Infrared spectroscopy confirmed the functionalization of PVA nanowebs. Functionalized nanowebs were characterized by evaluating their antimicrobi...