The size of conformational ensembles required for regular coverage of the conformational space of druglike molecules was examined. Using the conformer generation program Omega, the number of regularly distributed conformers (NRC) of flexible compounds was determined as a function of the root-mean-square deviation (RMSD) resolution of coverage. A regression equation was developed predicting the ...

A set of perception experiments, using reiterant speech, were designed to carry out a diagnostic of the segmentation / hierarchisation linguistic function of prosody. The prosodic parameters of F0, syllabic duration and intensity of the stimuli used during this experiment were extracted. Several dissimilarity measures (Correlation, root-mean-square distance and mutual information) were used to ...

The standard approach in positive political theory posits that action choices are the consequences of attitudes. Could it be, however, that an individual’s actions also affect her fundamental preferences? We present a broad theoretical framework that captures the simple, yet powerful, intuition that actions frequently alter attitudes as individuals seek to minimize cognitive dissonance. This fr...

ALTHOUGH PHYSICIANS COMPRISE FEWER THAN 2% OF MEMBERS OF CONgress, some of today’s most controversial political issues affect physician education, training, and practice, in addition to the public health. These issues include tort reform, abortion, bioterrorism, therapeutic and reproductive cloning, global warming, Medicare/Medicaid reform, and universal health coverage. The obstacles preventin...

The historically prevailing view in the network literature has been that relationships within networks develop gradually and cumulatively over time, with power playing what might be termed a ‘concrete’ role in such a process, based primarily on identifiable resource dependencies. The concept of (Foucauldian) ‘system power’, beginning to emerge in the management and organisation literature, is n...

With the business environment become more complex and dynamic, organizations have been faced with more pressures of competition. Organizations are often compelled to form strategic alliances with other organizations to survive and prosper. The inter-organizational arrangement can become favorable seedbed for inter-organization conflict. The participants in the strategic alliance often spend a s...

This paper generalizes the model proposed by Misra, by considering switching between political parties. In the model proposed, the movements of members from political party B to political party C and vice versa, are considered but the net movement is considered by assuming that [Formula: see text] (a constant), which implies that the movement of members is either from party B to party C or from...

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Public scientists were in a difficult position in this case. The results of their work were central to a social debate with high economic and political stakes. In certain cases their work was not judged according to its scientific merit but based on whether or not it supported the positions of some stakeholders. This situation tested the ability and courage of researchers to withstand pressure ...