Figure 1. Population structure of Pneumocystis carinii pneumonia (PCP) among African children as a function of cotrimoxazole prophylaxis. The total number of children is represented as A + B; the total number of children with PCP is represented as a + b. The ideal measure of risk, by cotrimoxazole use, of developing PCP is represented as (a/A)/(b/B). The actual measure of risk of developing PCP...

BACKGROUND The objective was to describe the causes of initial and overall AIDS-defining disease episodes among HIV patients in Singapore. METHODS A retrospective observational cohort study was performed of all adult patients seen at the national HIV referral center between 1985 and 2001. Data were extracted from the patients' records by ten trained healthcare workers. AIDS-defining condition...

A type of pneumonia due to the protozoon Pneumocystis carinii has been recognized in Europe for many years. There is frequent association with interstitial plasma cell pneumonia. Premature infants and debilitated full-term infants are chiefly affected, with peak incidence of infection occurring between 6 weeks and 4 months (Gajdusek, 1957). In recent years sporadic cases have been reported in G...

Eighteen children with pneumocystis carinii pneumonia diagnosed over a period of 16 years at a children's hospital are reviewed. All had an underlying disease, either congenital immunodeficiency or a malignancy. 15 patients were treated, 10 with pentamidine isethionate alone, 2 with both pentamidine and co-trimoxazole, and 3 with co-trimoxazole alone. 12 of the treated group recovered and the 3...

© 2010 The Authors. doi: 10.2340/00015555-0977 Journal Compilation © 2010 Acta Dermato-Venereologica. ISSN 0001-5555 Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse cutaneous reactions to drugs. We report here the first case of severe pneumonia caused by an unusual combined infection with Pneumocystis carinii (jiroveci), parainfluenza virus type 3, cytomeg...

BACKGROUND Detection of Pneumocystis jiroveci colonization in lungs or oral samples due to high sensitivity of PCR methods results in undue treatment of patients without any symptoms of Pneumocystis pneumonia. The aim of the present study is to demonstrate Pneumocystis carinii in rats, immune suppressed by oral and subcutaneous administration of dexamethasone. MATERIAL/METHODS Blood, oral, na...

F Miller During the first 10 years of the AIDS pandemic the clinical features of the syndrome have been extensively reported. By January 1992 there had been 5451 cases of AIDS in the United Kingdom, 3391 patients having died, and 16 828 people were known to have antibodies to the human immunodeficiency virus (HIV), with the potential to progress to AIDS. Pneumocystis carinii pneumonia, despite ...

We evaluated the usefulness of repeated nebulized saline induced sputum examinations among 60 HIV infected patients clinically suspected to have Pneumocystis carinii pneumonia (PCP). We found that the first sample was positive for 15 episodes (21.4%); the second sample was positive in 33 episodes (47.1%); the third sample was positive in 22 episodes (31.4%). Repeated nebulized saline induced sp...

Basic aspects of cell biology of Pneumocystis carinii are reviewed with major emphasis on its life cycle and the structural organization of the trophozoites and cyst forms. Initially considered as a protozoan it is now established that Pneumocystis belongs to the Fungi Kingdom. Its life cycle includes two basic forms: (a) trophozoites, which are haploid cells that divide by binary fission and m...

Bronchoalveolar lavage and transbronchial biopsy have been used as adjuncts to the management of patients with pneumonia associated with the acquired immunodeficiency syndrome (AIDS) at the Middlesex Hospital and the experience gained and difficulties encountered in the first five cases are reported. Widely varying organisms were isolated from lavage aspirates, some of which may have been nasop...