The 62nd annual Montagna Symposium on the Biology of Skin, “Light and Skin: How Light Sustains, Damages, Treats, Images and Modifies Skin Biology,” was held October 10–14, 2013, in Stevenson, Washington. Life and skin evolved under sunlight; dermatology will forever be entwined with photomedicine. We routinely use microscopy, optical diagnostics, phototherapy, photodynamic therapy and lasers wh...

Introduction: C-phycocyanin (C-PC), a photosynthetic protein obtained from Spirulina , is regarded highly promising commercially available biochemical. Numerous in vitro and vivo studies have provided evidence of C-PC’s ability to mitigate the inflammatory response, alleviate oxidative stress, facilitate wound healing. However, despite existing knowledge regarding protective mechanism against c...

Rhytidectomy is a surgery of balance and judgment. The goal is to create a refreshed and natural look by lifting the midcheek and jowl tissues and by smoothing the neck bands and excess skin. Facial aging, however, is only partially explained by gravity and descent of facial and neck tissues. Fat compartments in the face atrophy, bone remodels, and the skin undergoes chronological and photoagin...

Background: Skin is considered a reflection of person's appearance, so it normal if many people try to take care their skin, especially facial and retard the aging process. Dermoscopy quick, non-invasive technique that allows physicians observe skin. Different ethnic groups may show different signs on face. Medan multiethnic city thus might skin differently. This study aimed evaluate through De...

Ultraviolet A (UVA) irradiation plays a role in premature aging of the skin through triggering oxidative stress-associated stimulation of matrix metalloproteinase-1 (MMP-1) responsible for collagen degradation, a hallmark of photoaged skin. Compounds which can activate Nrf2, a transcription factor regulating antioxidant gene expression, should therefore serve as effective anti-photoaging agents...

A number of natural phytochemicals have anti-photoaging properties that appear to be mediated through the inhibition of matrix metalloproteinase-1 (MMP-1) expression, but their direct target molecule(s) and mechanism(s) remain unclear. We investigated the effect of naringenin, a major flavonoid found in citrus, on UVB-induced MMP-1 expression and identified its direct target. The HaCaT human sk...

Photoprotection is the primary preventive and therapeutic strategy against photoaging and skin cancer. This review presents the most important new advances in both topical and systemic photoprotection. Starting with innovations in the traditional physical and chemical filtering agents, we go on to discuss the growing number of antioxidants, the novel strategies for repairing light-induced DNA d...

UV skin exposure induces extensive generation of reactive oxygen species (ROS). These can react with DNA, proteins, fatty acids and saccharides causing oxidative damage. Such injuries result in a number of harmful effects: disturbed cell metabolism, morphological and ultrastructural changes, attack on the regulation pathways and, alterations in the differentiation, proliferation and apoptosis o...