Rapid, precise, accurate, and specific ratiospectra derivative spectrophotometry and a simple UV spectrophotometry using simultaneous equation methods are developed for the simultaneous determination of bisoprolol fumarate and hydrochlorothiazide from combined pharmaceutical dosage forms. For ratiospectra derivative spectrophotometry, the amplitudes were measured at 202.6 nm for bisoprolol fuma...

A simple, precise and cost effective spectrophotometric method have been developed for the estimation Atorvastatin and Nicotinic acid in combination in tablet dosage form by UV spectroscopy, using multi-component mode of analysis. Methanol used as solvent λmax of Atorvastatin and Nicotinic acid was found to be 248nm and 261.5nm respectively. The method shows linearity in the Atorvastatin and Ni...

A simple, sensitive and highly selective electrochemical method was developed for the simultaneous determination of nitazoxanide and ofloxacin in aqueous media (Britton-Robinson buffer, pH-8.36) on a hanging mercury drop electrode (HMDE) using differential pulse polarography (DPP). Using DPP a separation of about 936 mV between the peak oxidation potentials of nitazoxanide and ofloxacin present...

A simple accurate, sensitive reproducible spectrofluorimetric method was developed for the analysis of citalopram in pure and pharmaceutical dosage form. Citalopram showed strong native fluorescence in 0.05 M sulphuric acid having excitation at 239 nm and emission at 300 nm. All parameters like the effect of different solvents, pH, dilutions, reaction time, temperature and effect of excipients ...

Two simple, accurate and precise methods for simultaneous estimation of Esomeprazole and Itopride in bulk drug and tablet dosage form have been described. Method-A employs formation and solving of simultaneous equation using 231 and 370 nm as two analytical wavelengths. Method -B is Absorption ratio method, which uses 308 and 331 nm as two analytical wavelengths.Beer’s law was obeyed in the con...

Abstract Chemical mapping by Raman spectroscopy is widely used in the pharmaceutical industry to characterise distribution of components within tablets; however, current methods do not go beyond examining an exposed surface area a sample. There are known limitations with estimating domain size and shape statistics from 2D chemical images as values obtained will depend on where sectioned, potent...

Pharmaceutical tablets can be susceptible to damage such as edge chipping or erosion of the core during tablet coating process. The intersection certain process parameters, equipment design, and properties may induce more significant complete fracture. In this work, a hybrid predictive approach was developed using discrete element method (DEM) modeling lab-based impact experiments identify cond...

This learning's objective is to determine and investigate how pharmaceutical restrictions affect the characteristics of gastric floating tablets using diclofenac sodium (DICL) as a model for solubility enhancement, sodium-bicarbonate (NaHCO3) or calcium-carbonate (CaCO3). Hydroxypropyl Methylcellulose (HPMC) swelling polymer K100M K15M gas-forming substance. BY direct-compression manufacturing ...

The governments of many countries strongly support the production and clinical use of generic medicinal products which are “copies” of patented drugs and can be marked at lower cost. At present time bioequivalence testing is regarded as a useful methodology to perform comparisons among different products containing the same active ingredient. This report presents the results of comparative bioe...