OBJECTIVES Microvascular invasion and microlymphatic permeation are indicators of microscopic tumour invasion into small vessels and have been considered to be powerful prognostic indicators for non-small-cell lung cancer (NSCLC). Several studies have suggested that these should be included in the TNM classification, but, there have been conflicting results regarding the prognostic impact of mi...

Synopsis The effect of several variables on the in vitro permeation of urea through hairless mouse skin has been studied in order to determine the causes of an increasing permeability phenomenon found in studies with a range of hydrophilic compounds. The permeation of urea increased for a period of approximately 100 h after which a steady state permeation pattern was observed for approximately ...

In this study, the hydrogen permeation in the supercooled liquid state for Ni65Nb25Zr10, Ni60Nb20Zr20 and Ni55Nb15Zr30 metallic glasses was investigated in conjunction with the discussion on the effect of hydrogen diffusion on hydrogen permeation. The hydrogen permeation of the Ni65Nb25Zr10 and Ni60Nb20Zr20 metallic glasses increases significantly by the transition from the glassy solid state t...

comnode classification within membrane residue curves (m-rcms) currently hinges on lyapunov’s theorem and therefore the computation of mathematically complex eigenvalues. this paper presents an alternative criterion for the classification of nodes within m-rcms based on the total membrane flux at node compositions. this paper demonstrates that for a system exhibiting simple permeation behaviour...

objective(s) in this study, a kind of ph sensitive composite membrane was prepared and drug permeation through it was investigated in terms of ph. rationale of this study originated from the fact that a ph change which may be a result of a disease state in the body can trigger drug release. materials and methods  here, a kind of ph sensitive composite membrane containing different nanoparticle ...

The oxygen permeation performance of Ba0.5Sr0.5Co0.8Fe0.2O3−δ (BSCF) mixed-conducting multichannel hollow fiber (MCMHF) membranes was improved by surface modification via spin-spraying of a La0.6Sr0.4CoO3−δ (LSC) porous layer. At 1173 K, the oxygen permeation flux of the modified membranes was clearly enhanced and reached 9.68 mL·cm−2·min−1, which is a remarkable high value in the field of mixe...

Tocopherol represents a big challenge for transdermal permeation owing to its extreme hydrophobicity and large molecular mass. The aim of the present study was to develop alpha-tocopherol (T) topical formulations and evaluate their ex vivo and in vivo permeation. Franz diffusion cells were used for ex vivo permeation, and neonatal rats were used for in vivo permeation. Seven gel formulations an...

This study aimed to formulate an optimized acyclovir (ACV) nanoemulsion hydrogel in order to provide a solution for the slow, variable, and incomplete oral drug absorption in patient suffering from herpes simplex viral infection. Solubility of ACV in different oils, surfactants, and cosurfactants was explored utilizing a cubic model mixture design to obtain a nanoemulsion with minimum globule s...

Nicotine transdermal systems are being used as an aid to smoking cessation programs. As the kinetics of nicotine delivery is important in success of a smoking cessation program, rapid and high input of nicotine is required, which is not possible by passive methods and requires enhancement strategies such as iontophoresis. Iontophoretic permeation, of nicotine looks promising, based on published...