percutaneous vertebroplasty is a promising therapeutic technique for pain control in patients with pathologic fractures of vertebral bodies. percutaneous vertebroplasty is an appropriate treatment for vertebral pathologic fractures, which is resistant to other usual treatment. it is a useful and only choice in special cases, because of less tissue damage and there is no risk of open surgery and...

Many properties of chemicals depend on their streochemistry. Among these, the effects of streoisomerism on percutaneous absorption of drugs, which is subject of the present investigation, is not well studied yet. In this study, tretinoin (TT) and isotretinoin (ITT) (geometric isomers) were chosen and their permeations (alone or in the presence of each other) through enhancer-treated excised ...

There is a lack of studies on Pentravan cream, a widespread transdermal vehicle which is used by compounding pharmacies. The purpose of this study was to evaluate this transdermal vehicle. The permeation performance for progesterone, estradiol, and estriol in formulations containing each of those drugs separately, as well as an association of estradiol + estriol (Biest), was evaluated regarding...

OBJECTIVES To study the influence of the presence of water on the dermal absorption of 2-butoxyethanol (BE) in volunteers. METHODS Six male volunteers were dermally exposed to 50%, 90% or neat w/w BE for 4 h on the volar forearm over an area of 40 cm(2). An inhalation exposure with a known input rate and duration served as a reference dosage. The dermal absorption parameters were calculated f...

Transdermal patches loaded with pravastatin was previously characterized in another published study by Serrano-Castañeda et al; 2015. These transdermal patches (TP) were generated by the plate casting technique, the in vitro percutaneous absorption studies of TP were evaluated for three different formulations of TP with different quantities of Pluronic F-127 (PF-127): i) without PF-127 (TP W), ...

Laser-induced thermotherapy (LITT) is an established minimally invasive percutaneous technique of tumor ablation. Nevertheless, there is a need to predict the effect of laser applications and optimizing irradiation planning in LITT. Optical attributes (absorption, scattering) change due to thermal denaturation. The work presents the possibility to identify these temperature dependent parameters...

Topica! tyrosine has been proposed as a tanning accelerator because tyrosine is a precursor of melanin. We tested formulations containing O, 1, and 2% L-tyrosine topically on 14 individuals daily for 28 days. Percutaneous absorption using "C tyrosine was 1.23% in 24 hr. No enhanced pigmentation was clinically evident in any of the subjects. In this study, we were unable to demonstrate that topi...

a relatively constant amount of dieldrin, a chlorinated hydrocarbon insecticide, is directly related to obesity. This relationship should be applicable regardless of the route of absorption of dieldrin (ingestion, inhalation, or percutaneous). Forced feeding of a high calorific value food appears to have a place in the treatment of dieldrin poisoning and, by extension, in the treatment of poiso...

We evaluated the pharmacokinetics and safety of the antimicrobial agent triclosan after dermal application of a 2% triclosan-containing cream to six volunteers. Percutaneous absorption calculated from urinary excretion was 5.9% +/- 2.1% of the dose (mean +/- standard deviation). The amount absorbed suggests that daily application of a standard adult dose would result in a systemic exposure 890 ...

Dermal exposure to jet fuels has received increased attention with the recent release of newer fuels with novel performance additives. The purpose of these studies was to assess the percutaneous absorption and cutaneous disposition of topically applied (25 microl/5 cm(2)) neat Jet-A, JP-8, and JP-8(100) jet fuels by monitoring the absorptive flux of the marker components 14C naphthalene and (3)...