نتایج جستجو برای: paraquat dichloride

تعداد نتایج: 5267  

Journal: :Lancet 1979
A T Proudfoot M S Stewart T Levitt B Widdop

Plasma-paraquat concentrations were measured in 79 patients who had ingested liquid or granular weedkillers containing paraquat. At any given time after ingestion, the plasma-paraquat concentrations in the patients who died usually exceeded those in the survivors. It is suggested that measurement of plasma-paraquat concentrations is useful in assessing the severity and predicting the outcome of...

Journal: :Renal failure 2007
Andreas Soloukides Dimitrios-Anestis Moutzouris Theodore Kassimatis Georgios Metaxatos Valsamakis Hadjiconstantinou

Paraquat is a pesticide widely used in agriculture. Numerous cases of paraquat intoxication have been reported either accidentally or intentionally as a suicidal attempt. The most severe cases of paraquat poisoning refer to oral ingestion. Complications include respiratory, hepatic, and renal failure, and are usually fatal. Dermal exposure is less frequent and rarely fatal. This article reports...

Journal: :Chest 1999
C H Kao J F Hsieh Y J Ho D Z Hung T J Lin H J Ding

STUDY OBJECTIVES Paraquat, a widely used herbicide, has been shown to cause severe and often fatal pulmonary fibrosis in humans and laboratory animals. Although paraquat is known to be directly cytotoxic to lung parenchyma, changes in routine lung scintigraphy results after acute paraquat intoxication have not been reported. The objective of this project was to investigate changes in lung venti...

1999
Mohamed A Dalvie Neil White Ricky Raine Jonathan E Myers Leslie London M Thompson D C Christiani

Objective—To evaluate the possible effects of paraquat spraying among workers on deciduous fruit farms in the Western Cape, South Africa. Paraquat is a commonly used herbicide world wide and is a well documented cause of pulmonary fibrosis in studies of laboratory animals and in humans after exposure to a high dose (usually accidental or as parasuicide). The respiratory eVects of long term, low...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2011
Rachel M Bartlett Dhanabalan Murali R Jerome Nickles Todd E Barnhart James E Holden Onofre T DeJesus

Prenatal in utero conditions are thought to play a role in the development of adult diseases including Parkinson's disease (PD). Paraquat is a common herbicide with chemical structure similar to 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine, a neurotoxin known to induce parkinsonism. In order to assess the role of in utero paraquat exposure in PD, uptake in maternal and fetal brains were measure...

Journal: :Free radical biology & medicine 2008
Mohamed Samai Theresa Hague Declan P Naughton Paul R Gard Prabal K Chatterjee

Superoxide anion generation plays an important role in the development of paraquat toxicity. Although superoxide dismutase mimetics (SODm) have provided protection against organ injury involving generation of superoxide anions, they often suffer problems, e.g., regarding their bioavailability or potential pro-oxidant activity. The aim here was to investigate and compare the therapeutic potentia...

2017
Flora A. Milton Mariella G. Lacerda Simone B. P. Sinoti Pedro G. Mesquita Dileesh Prakasan Michella S. Coelho Caroline L. de Lima Alexandre G. Martini Gabriela T. Pazzine Maria de F. Borin Angelica A. Amato Francisco de A. R. Neves

Organotins are a group of chemical compounds that have a tin atom covalently bound to one or more organic groups. The best-studied organotin is tributyltin chloride, which is an environmental pollutant and an endocrine disruptor. Tributyltin chloride has been shown to bind to PPARγ/RXRα and induces adipogenesis in different mammalian cells. However, there are few studies with other organotin co...

Journal: :Bulletin of the World Health Organization 1993
G Chester G Gurunathan N Jones B H Woollen

Absorption of the herbicide paraquat (1,1'-dimethyl-4,4'-bipyridinium) by mixer-loaders and spray operators on a Sri Lankan tea plantation was assessed over five consecutive days of spraying. Beginning on the day before spraying started and continuing for each of the five spraying days and for seven days after the last day of spraying, 24-hour urine samples were collected from each of the worke...

Journal: :QJM : monthly journal of the Association of Physicians 2003
M Eddleston M F Wilks N A Buckley

BACKGROUND Acute paraquat self-poisoning is a significant problem in parts of Asia, the Pacific and the Caribbean. Ingestion of large amounts of paraquat results in rapid death, but smaller doses often cause a delayed lung fibrosis that is usually fatal. Anti-neutrophil ('immunosuppressive') treatment has been recommended to prevent lung fibrosis, but there is no consensus on efficacy. AIM To...

Journal: :Acta Crystallographica Section E Structure Reports Online 2008

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