Endoscopic ultrasound (EUS) has evolved from being primarily a diagnostic modality into an interventional endoscopic tool for the management of both benign and malignant gastrointestinal illnesses. EUS-guided therapy has garnered particular interest as a minimally invasive approach for the treatment of pancreatic cancer, a disease often complicated by its aggressive course and poor survival. Th...

BACKGROUND Histologic characteristics have proven to be very useful for classifying different types of tumors of the pancreas. As a result, the major tumor types in the pancreas have long been classified based on their microscopic appearance. MAIN BODY Recent advances in whole exome sequencing, gene expression profiling, and knowledge of tumorigenic pathways have deepened our understanding of...

CONTEXT KRAS mutations play an important role in pancreatic cancer. GNAS mutations were discovered in intraductal papillary mucinous neoplasms (IPMN). OBJECTIVES Our aim was to identify the frequency of KRAS and GNAS mutations in pancreatic cystic neoplasms and pancreatic ductal adenocarcinoma (PDAC). METHODS Sixty-eight surgically resected formalin fixed, paraffin embedded pancreatic speci...

Abstract Background Pancreatic cancer is one of the most significant causes and lethal malignant neoplasms in world death developed nations. It was named “silent killer” for its quiet course, late clinical presentation, trend rapid growth. The aim this study to detect reliability multidetector CT (MDCT) as diagnostic tool assessing possibility eradicating pancreatic cancer. Results Twenty-four ...

OBJECTIVE To assess changing patterns in the detection and outcomes of pancreatic neuroendocrine neoplasms (PNENs). DESIGN Retrospective review from May 21, 1977, through September 16, 2005. SETTING Massachusetts General Hospital, a tertiary care center. PATIENTS We evaluated 168 patients (51% male; mean age, 56 years) who underwent surgery for histologically confirmed PNENs. MAIN OUTCO...

CONTEXT Perivascular epithelial cell tumors (PEComas) are a family of rare mesenchymal neoplasms which share cellular, immunohistochemical and ultrastructural characteristics but are found in different visceral and soft tissue sites. PEComas of the pancreas are extremely rare neoplasms. CASE REPORT We describe a 49-year-old male who was incidentally diagnosed with a pancreatic mass. Endoscopi...

BACKGROUND The incidence of pancreatic neuroendocrine neoplasms (pNEN) is increasing. This study aimed to evaluate predictors of overall survival and the indication for surgery. METHODS Data collected between October 2001 and December 2012 were analysed. Histological grading and staging was based on the classifications of the World Health Organization, the International Union Against Cancer a...

Diagnosing Pancreatic Cysts Doctors use computed tomography (CT) or magnetic resonance imaging(MRI)scanstodiagnosepancreaticcystsanddeterminetheir type. These tests can also identify features of the cysts that suggest an increased risk of cancer. If imaging scans cannot identify the typeof cyst or if the cyst has aconcerningappearance,doctorsmayalsouseanendoscopicultrasound procedure. This invo...

Cystic tumors of the pancreas account for less than 10% of pancreatic neoplasms. Intraductal papillary mucinous carcinomas (IPMNs) account for 21-33% of these tumors. IPMNs represent papillary neoplasms within the main pancreatic duct and/or side branches showing mucin hypersecretion that often leads to duct dilation and chronic obstructive pancreatitis [1]. A 55-year-old patient presented with...

Studies of pancreatic cancer in the setting of second primary malignant neoplasms can provide etiologic clues. An international multicenter study was carried out using data from 13 cancer registries with a registration period up to year 2000. Cancer patients were followed up from the initial cancer diagnosis, and the occurrence of second primary malignant neoplasms was compared with expected va...