نتایج جستجو برای: p53 expression

تعداد نتایج: 898809  

Journal: :International journal of oncology 2010
Wenjing Zhang Zheng Guo Bo Jiang Lingyun Niu Guosheng Xia Xinying Wang Tianming Cheng Yusheng Zhang Jide Wang

It has been reported that XAF1 expression in gastric cancer is negatively correlated with p53. Our purpose was to clarify the regulatory mechanism of p53 on XAF1 expression. The effects of overexpressed wild-type and mutant p53 on XAF1 expression were evaluated. Binding capacity of core XAF1 promoter sequence to the recombinant p53 protein was examined. Site-directed mutation of putative p53 bi...

Journal: :acta medica iranica 0
f. ensani n. hajsadeghi f. amoozegar-hashemi p. haddad

the molecular basis of metastatic potential of human breast carcinoma cells can be useful information to determine the practical implications in the diagnosis, determining prognosis and treatment of breast cancer. the aim of this study was to identify predictors of aggressive biological behavior and metastatic potential in breast carcinoma among a number of intrinsic biomarkers of tumor cells. ...

Journal: :Cancer research 1994
A Albor D M Flessate T Soussi V Notario

The expression of the tumor suppressor gene p53 was studied in Syrian hamster embryo cells neoplastically initiated with a single dose of 3-methylcholanthrene. Ten randomly selected individual 3-methylcholanthrene-transformed colonies were established in culture independently. Eight of these cell lines contained levels of p53 mRNA similar to those in primary embryo cells (p53+ cell lines), as m...

2017
Yonggang Dai Xiaoguang Wang Hongxia Hu

Objective: This study aimed to explore ultrasound-guided injections of Ultrasound Contrast Agents (UCAs) and p53 gene for the treatment of rats with breast cancer. Methods: With the construction of p53 expression vector and rat model with breast cancer, 160 rats that modeled successfully were randomly divided into 4 groups: p53 gene introduction group, p53 gene introduction+ultrasound irradiati...

Journal: :iranian biomedical journal 0
معصومه عبدالهی maasoume abdollahi مژده صالح نیا mojdeh salehnia ساغر صالح پور saghar salehpour نسیم قربانمهر nassim ghorbanmehr

background: in this study, we evaluated the incidence of apoptosis at the ultrastructural levels and expression of some apoptosis-related genes in vitrified human ovarian tissue just after warming. methods: human ovarian tissue biopsies from 23 women after caesarean section were transported to the laboratory within 2 hours, and then they were cut into small pieces. some pieces were vitrified an...

Eraj Nowrouzian Hasti Azarabad, Mohammad Javad Gharagozlou Seyed Mohammad Karbalaree Seyed Javad

Role of the protein overexpression is very important in the pathogenesis, diagnosis and prognosis of neoplasia. Cases of overexpression of p53 and Ki67 proteins were investigated in 19 ocular squamous cell carcinomas (OSCC) in dairy cows. Microscopically, insix cases the tumors were carcinoma in situ (noninvasive carcinoma, G0), and in the remaining 13 cases the tumors were invasive carcinoma. ...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2000
T Itoshima T Fujiwara T Waku J Shao M Kataoka W G Yarbrough T J Liu J A Roth N Tanaka M Kodama

Transcriptional factor E2F-1 as well as tumor suppressor p53 have been shown to cause apoptosis independently in some types of human cancer cells when overexpressed. Here we report that sequential transfer of the wild-type p53 and E2F-1 genes efficiently induces apoptosis in human esophageal cancer cells and that E2F-1 overexpression directly, activates expression of p14 (ARF), which inhibits M...

2013
Oliver Couture Eric Lombardi Kendra Davis Emily Hays Nalini Chandar

The tumor suppressor gene p53 is involved in a variety of cellular activities such as cellular stress responses, cell cycle regulation and differentiation. In our previous studies we have shown p53's transcription activating role to be important in osteoblast differentiation. There is still a debate in the literature as to whether p53 inhibits or promotes differentiation. We have found p53 hete...

Journal: :Türk biyokimya dergisi 2021

Abstract Objectives The aim of this study is to investigate the effects radiofrequency radiation (RFR) on apoptosis, proliferation, stress response, and inflammation markers in colorectal cancer cells. Methods We tested intermittent exposure RFR at different frequencies two cell lines; HCT-116 DLD-1. Protein levels were subsequently analyzed by ELISA. Results led a decrease P53, p-P53, p-P38, p...

Journal: :American journal of clinical pathology 2010
Hong Chang Allan M Jiang Connie X Y Qi

Hemizygous TP53 gene deletion is the most important adverse risk factor in chronic lymphocytic leukemia (CLL), but its relationship with p53 protein expression is unclear. We investigated 110 CLL cases and correlated nuclear p53 protein immunoreactivity with TP53 gene deletion status and other CLL-associated genetic risk factors. Fluorescence in situ hybridization detected hemizygous TP53 delet...

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