Antipsychotic-induced thrombocytopenia is generally rare, but seems to occur more frequently with quetiapine. Accordingly, the relative risk of thrombocytopenia can be described as very rare with loxapine and clozapine (o 0.01%), uncommon with risperidone (X 0.1%, o 1%), but very common with quetiapine (X 10%). However, very few cases are reported in the literature, with one published case of i...

Cross-reactivities of some over-the-counter and uncontrolled prescription drugs with the immunoassays of some classes of drugs of abuse have been reported (1–17). Chemical structure similarity is a cause for cross-reactivity in immunoassays because the cross-reacting compound can fit onto the active sites in the antibody that has been developed for the drug of abuse or its chemical class. Howev...

J. CRAIG VENTER, LULE J. ARNOLD, JR. AND NATHAN 0. KAPLAN. The Structure and Quantitation of Catecholamines Covalently Bound to Glass Beads 1 NGUYEN B. ThoA, G. FREDERICK WOOTEN, JULIUS AXELROD AND IRwIN J. K0PIN. On the Mechanism of Release of Norepinephrine from Sympathetic Nerves Induced by Depolarizing Agents and Sympathomimetic Drugs 10 J. T. HOLDEN, J. ROSSIER, J. C. BEAUJOUAN, P. GUYENET...

their metabolism. The problem of the ecological effects of these insecticides is not discussed in detail. The review by Kinsky of "Antibiotic interactions with model membranes" deals with the fascinating class of compounds that can do tricks like incarcerating potassium ions in a clathrate cage, allowing them to pass with relative ease through the normally hostile hydrophobic territory of lipid...

The quantification of drug metabolites produced during drug metabolism is a growing concern for the pharmaceutical industry, regulatory agencies such as the US Food and Drug Administration, the European Medicines Agency, and others. As 70% of drugs are known reactive metabolites and have black box warnings, they are a major cause of drug-induced injury and lead to drug attrition in early or lat...

Mrs. A. B., aged 56, developed angina pectoris in 1970 and in 1972 was put on practolol 100 mg three times a day in addition to oxazepam 15 mg three times a day and digoxin 0-25 mg twice a day which she had been having since 1971. She developed a rash on her hands, which spread rapidly, and a dry lumpy sensation in her eyes, with reduced secretion of tears. In March 1974 she first noticed abdom...

BACKGROUND Pain management is a high priority for patients with rheumatoid arthritis (RA). Muscle relaxants include drugs that reduce muscle spasm (for example benzodiazepines such as diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan) and non-benzodiazepines such as metaxalone (Skelaxin) or a combination of paracetamol and orphenadrine (Muscol)) and drugs that prevent increased muscle to...

Objectives: The objectives of this preliminary study were to identify a cohort of patients receiving outpatient prescriptions for a class of medications, benzodiazepines, that are known to increase the risk of adverse events, and to analyze the temporal association between outpatient benzodiazepine usage and inpatient and outpatient injury-related health care encounters for this cohort. Methods...

A six-session intervention for harmful alcohol use was piloted via a 24-hour alcohol and other drug (AOD) helpline, assessing feasibility of telephone-delivered treatment. The intervention, involving practice elements from Motivational Interviewing, Cognitive-Behavioral Therapy, and node-link mapping, was evaluated using a case file audit (n = 30) and a structured telephone interview one month ...