Early detection of oral premalignant lesions (OPMLs) by visual inspection with toluidine blue has not been addressed. We conducted a community-based randomized controlled trial to assess whether using toluidine blue as an adjunctive tool for visual screening had a higher detection rate of OPMLs and could further reduce the incidence of oral cancer. In 2000, in Keelung, we randomly assigned a to...

Oral submucous fibrosis (OSMF) is a potentially malignant oral condition effectively linked to the causative habit of chewing areca nut. Since its first description in the 1950s, numerous epidemiological, biochemical, histological, and genetic studies have been reported. While most studies point out to the cause and effect of areca nut, co-additive factors are also implicated in the progression...

Analysis of histopathological sections by image analysis software and Immunohistochemical localization for investigation of different protein expression patterns can be used as a valued tool for detection of progress of malignancy in oral cancer. The present study has applied microscopic analysis for different sections of oral precancerous conditions and lesions such as Oral Submucous Fibrosis,...