AIM To study the normal distributions of mitochondria and voltage gated Na+ channels in the human optic nerve head in order to gain insight into the potential mechanisms of optic nerve dysfunction seen in the inherited optic neuropathies. METHODS Five fresh frozen human optic nerves were studied. Longitudinally orientated, serial cryosections of optic nerve head were cut for mitochondrial enz...

The optic nerve and chiasm, obtained at autopsy, from 53 cases with clinical histories of cerebrovascular disturbances were histopathologically investigated, and ischemic changes in the posterior portion of the optic nerve were revealed in 12 cases. The progress of posterior ischemic optic neuropathy might be divided into necrotic, liquefactive and scar stages. The lesions were located in the t...

of Bruch'-s membrane at the optic n-erve. Three cases of partial cross ruptures of the optic nerve are reported histologically. All three are discovered at the very insertion of the lamina elastica chorioideae. The tear was caused in all cases (traumatic, expulsive haemorrhage and haemorrhagic glaucoma) by an instantaneous, probably arterial, subiretinal bleeding. Traumatic retropulsion of the ...

Nerve fibers originating in the retina follow a specific topographical arrangement in the optic nerve and chiasm. Compressive lesions at the junction of the intracranial optic nerve and optic chiasm can produce characteristic visual field defects. Optic nerve involvement at the junction of the optic chiasm results in unilateral visual field loss. If fibers from the inferonasal retina of the con...

The axons that make up the optic nerve originate from the retinal ganglion cells and extend from there to the lateral geniculate body. If cellular integrity is interrupted by disease anywhere along the course of an axon, degeneration occurs in both directions from the point of insult. Thus, axon frag­ ments between the site of injury and the lat­ eral geniculate body are separated from their nu...

BACKGROUND Developmental delay has been reported to occur with optic nerve hypoplasia, a leading cause of pediatric blindness, but has not been systematically examined for its prevalence and correlation with associated pathologies of optic nerve hypoplasia. OBJECTIVE The purpose of this study was to determine the developmental outcomes of children with optic nerve hypoplasia and the correlati...

PURPOSE Cytoskeleton proteins play a critical role in maintaining retinal ganglion cell structure, viability, and function. This study documents the distribution of cytoskeleton protein subunits in the various regions of the normal human optic nerve and identifies important relationships among mitochondria, myelin, and neurofilament proteins. METHODS Twenty-three optic nerves from human cadav...

BACKGROUND AND PURPOSE There is a well-known relationship between MS and damage to the optic nerve, but advanced, quantitative MR imaging methods have not been applied to large cohorts. Our objective was to determine whether a short imaging protocol (< 10 minutes), implemented with standard hardware, could detect abnormal water diffusion in the optic nerves of patients with MS. MATERIALS AND ...

OBJECTIVE To report severe ocular injuries caused by pointed door handles in children. DESIGN Noncomparative, interventional, retrospective case series. METHODS Clinical records of 15 patients who sustained severe ocular injuries from door handles were reviewed for place of trauma, presenting symptoms and signs, surgical procedures performed, and final outcome. MAIN OUTCOME MEASURES Traum...