نتایج جستجو برای: oligoclonal bands
تعداد نتایج: 49577 فیلتر نتایج به سال:
Challenging diagnosis of myelin oligodendrocyte glycoprotein (MOG) antibody: positive optic neuritis
Case presentation: Ten year-old female presented whit visual loss and ocular pain with extraocular movements in the left eye papilledema. After 15 days, it progressed to right eye. No other neurological symptoms were observed. The case was investigated optical nerve magnetic resonance imaging (MRI), which evidenced enhancement of perineural involvement, brain spinal cord MRI without demyelinati...
A 72-year-old woman presented with a 6-week history of gait disturbance and mild consciousness. For 9 months, she had been treated for advanced non-small cell lung cancer atezolizumab. MRI revealed symmetrical high signal in the thalamus bilaterally (figure). She did not have evidence recurrence or metastases. Serum autoimmune antibodies were absent (anti-AQP4, anti-MOG, anti-amphiphysin, CV2, ...
OBJECTIVES Antibodies to myelin oligodendrocyte glycoprotein (MOG) are detectable in inflammatory demyelinating CNS diseases, and MOG antibody-associated diseases seem to have a better prognosis despite occasionally severe presentations. METHODS We report the case of a 71-year-old patient with acute visual and gait disturbance that dramatically worsened to bilateral amaurosis, tetraplegia, an...
OBJECTIVE To investigate whether oligoclonal T cell populations occur in peripheral blood lymphocytes from patients with systemic lupus erythematosus (SLE). METHODS RNA was extracted from the lymphocytes isolated from whole peripheral blood of five female patients fulfilling ARA criteria for SLE and two healthy female controls, and synthesised into cDNA. CDR3 length spectratyping was performe...
OBJECTIVE Intrathecal IgG synthesis, persistence of bands of oligoclonal IgG, and memory B-cell clonal expansion are well-characterized features of the humoral response in multiple sclerosis (MS). Nevertheless, the target antigen of this response remains enigmatic. METHODS We produced 53 different human IgG1 monoclonal recombinant antibodies (rAbs) by coexpressing paired heavy- and light-chai...
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