نتایج جستجو برای: new isoform

تعداد نتایج: 1873501  

Journal: :Metallomics : integrated biometal science 2014
Narasimha Rao Uda Grégory Upert Gaetano Angelici Stefan Nicolet Tobias Schmidt Torsten Schwede Marc Creus

The development of resistance to virtually all current antibiotics makes the discovery of new antimicrobial compounds with novel protein targets an urgent challenge. The dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) is an essential metallo-enzyme for growth and proliferation in many bacteria, acting in the desuccinylation of N-succinyl-L,L-diaminopimelic acid (SDAP) in a ...

2014
Yanyi Chen Shenghui Xue Juan Zou Jose R. Lopez Jenny J. Yang Claudio F. Perez

Passive SR (sarcoplasmic reticulum) Ca2+ leak through the RyR (ryanodine receptor) plays a critical role in the mechanisms that regulate [Ca2+]rest (intracellular resting myoplasmic free Ca2+ concentration) in muscle. This process appears to be isoform-specific as expression of either RyR1 or RyR3 confers on myotubes different [Ca2+]rest. Using chimaeric RyR3-RyR1 receptors expressed in dyspedi...

Journal: :Physiological genomics 2000
P L Sinn C D Sigmund

We have reported that mice transgenic for 140- and 160-kb P1 phage artificial chromosomes (PACs) containing the human renin gene express the gene in a highly tissue-restricted and regulated manner. Herein, we demonstrate that the transgene is also expressed appropriately throughout development. In the course of this investigation, we identified the existence of three transcriptional isoforms of...

Journal: :Molecular pharmacology 2004
Oliver H Wittekindt Violeta Visan Hiroaki Tomita Faiqa Imtiaz Jay J Gargus Frank Lehmann-Horn Stephan Grissmer Deborah J Morris-Rosendahl

We have isolated an hSK3 isoform from a human embryonic cDNA library that we have named hSK3_ex4. This isoform contains a 15 amino acid insertion within the S5 to P-loop segment. Transcripts encoding hSK3_ex4 are coexpressed at lower levels with hSK3 in neuronal as well as in non-neuronal tissues. To investigate the pharmacokinetic properties of hSK3_ex4, we expressed the isoforms hSK3 and hSK3...

Journal: :Gene 2004
Feng-Qi Zhao Yucai Zheng Bing Dong Takami Oka

The ubiquitously expressed transcription factor Oct-1, a member of the POU domain factors, is involved in the regulation of expression of many tissue-specific and house-keeping genes. Multiple alternatively spliced isoforms of Oct-1 have been identified in human and mouse cells. The expression patterns of these isoforms and the analysis of their genomic organization and structure have suggested...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
Allon Goldberg Derek E Wildman Timothy R Schmidt Maik Huttemann Morris Goodman Mark L Weiss Lawrence I Grossman

Cytochrome c oxidase (COX) is a 13-subunit protein complex that catalyzes the last step in mitochondrial electron transfer in mammals. Of the 10 subunits encoded by nuclear DNA (three are mtDNA products), some are expressed as tissue- and/or development-specific isoforms. For COX subunit VIII, previous work showed that expression of the contractile muscle-specific isoform gene, COX8H, is absent...

Journal: :Nucleic acids research 1993
P Babij

Previous work demonstrated that the rabbit smooth muscle myosin heavy chain gene showed sequence divergence at the 25kDa/50kDa junction of the S1 subfragment when compared to chicken gizzard and chicken epithelial nonmuscle myosin. RNase protection analysis with a probe spanning this region detected two partially protected fragments which were not present in RNA from vascular tissue and only fo...

2018
Jose Manuel Rodriguez Juan Rodriguez-Rivas Tomás Di Domenico Jesús Vázquez Alfonso Valencia Michael L. Tress

The APPRIS database (http://appris-tools.org) uses protein structural and functional features and information from cross-species conservation to annotate splice isoforms in protein-coding genes. APPRIS selects a single protein isoform, the 'principal' isoform, as the reference for each gene based on these annotations. A single main splice isoform reflects the biological reality for most protein...

Journal: :Cytokine 1997
H L Glansbeek P M van der Kraan F P Lafeber E L Vitters W B van den Berg

Recently, a new isoform of the type II transforming growth factor beta receptor (TGF-beta RII) was identified. This isoform (TGF-beta RII2) contains an insertion of 25 amino acids in the extracellular domain of the receptor. Using RT-PCR the authors demonstrated that both TGF-beta RII1 and TGF-beta RII2 are expressed by chondrocytes in murine and human articular cartilage. Bovine articular chon...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005
Mahmood Amiry-Moghaddam Heidi Lindland Sergey Zelenin Bjørg A Roberg Brigitta B Gundersen Petur Petersen Eric Rinvik Ingeborg A Torgner Ole P Ottersen

Aquaporins are a family of water channels found in animals, plants, and microorganisms. A subfamily of aquaporins, the aquaglyceroporins, are permeable for water as well as certain solutes such as glycerol, lactate, and urea. Here we show that the brain contains two isoforms of AQP9--an aquaglyceroporin with a particularly broad substrate specificity--and that the more prevalent of these isofor...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید