نتایج جستجو برای: neurotoxicity syndromes

تعداد نتایج: 85645  

2017
Kohei Yuyama Yasuyuki Igarashi

The intracerebral level of the aggregation-prone peptide, amyloid-ß (Aß), is constantly maintained by multiple clearance mechanisms, including several degradation enzymes, and brain efflux. Disruption of the clearance machinery and the resultant Aß accumulation gives rise to neurotoxic assemblies, leading to the pathogenesis of Alzheimer's disease (AD). In addition to the classic mechanisms of ...

2012
Xi Lei Qihao Guo Jun Zhang

Compelling evidence has shown that exposure to anesthetics used in the clinic can cause neurodegeneration in the mammalian developing brain, but the basis of this is not clear. Neurotoxicity induced by exposure to anesthestics in early life involves neuroapoptosis and impairment of neurodevelopmental processes such as neurogenesis, synaptogenesis and immature glial development. These effects ma...

Journal: :Biophysical journal 2013
Robin D Johnson Joseph A Schauerte Chun-Chieh Chang Kathleen C Wisser John Christian Althaus Cynthia J L Carruthers Michael A Sutton Duncan G Steel Ari Gafni

Soluble oligomers of the amyloid-β peptide have been implicated as proximal neurotoxins in Alzheimer's disease. However, the identity of the neurotoxic aggregate(s) and the mechanisms by which these species induce neuronal dysfunction remain uncertain. Physiologically relevant experimentation is hindered by the low endogenous concentrations of the peptide, the metastability of Aβ oligomers, and...

2016
Antonia Nicole Klein Tamar Ziehm Markus Tusche Johan Buitenhuis Dirk Bartnik Annett Boeddrich Thomas Wiglenda Erich Wanker Susanne Aileen Funke Oleksandr Brener Lothar Gremer Janine Kutzsche Dieter Willbold

The aggregation of amyloid-β (Aβ) is postulated to be the crucial event in Alzheimer's disease (AD). In particular, small neurotoxic Aβ oligomers are considered to be responsible for the development and progression of AD. Therefore, elimination of thesis oligomers represents a potential causal therapy of AD. Starting from the well-characterized d-enantiomeric peptide D3, we identified D3 deriva...

Journal: :Cancer research 1987
R Pazdur B G Redman T Corbett M Phillips L H Baker

Phase I evaluation of spiromustine was performed using an every-3-week schedule and a weekly X 3 schedule. Neurotoxicity was the dose-limiting toxicity presenting as alterations in cortical integrative functions (orientation, language, coordination), leading to a decrease in the level of consciousness. Traditional criteria for grading neurotoxicity poorly characterized these toxicities. The max...

Journal: :NIDA research monograph 1996
F H Gawin M E Khalsa-Denison

Pharmacological sensitization is defined as an increasing effect of a given drug dose after repeated administrations. Detected over 65 years ago during observations of animal behavior, sensitization provided an anti-thesis to the concept of pharmacological tolerance. In modern neuro-science, the sensitization concept has evolved to reflect neuroadaptive, or perhaps neurotoxic, processes and pha...

2014
Mohamed I. Attia Mohamed N. Aboul-Enein Aida A. El-Azzouny Yousreya A. Maklad Hazem A. Ghabbour

Anticonvulsant potential and neurotoxicity of certain new imidazole-containing arylsemicarbazones 6a-p are reported. The test compounds 6a-p exhibited anticonvulsant activity mainly in the scPTZ screen. Compound 6p emerged as the most active surrogate displaying 100% protection at a dose level of 636 μ mol/kg in the scPTZ screen without any neurotoxicity. The assigned (E)-configuration of the t...

2005
R. Yakupov L. Chang D. Alicata D. Ramones C. Cloak T. Ernst

INTRODUCTION: Methamphetamine (METH) is a major drug of abuse in the United States and in many countries throughout the world. Preclinical and clinical studies demonstrated significant neurotoxic effects and brain changes associated with the drug. However, few studies have evaluated morphometric changes associated with METH abuse [1-3]. We performed voxel based morphometry to determine whether ...

Journal: :The Journal of neuropsychiatry and clinical neurosciences 2003
Thomas E Nordahl Ruth Salo Martin Leamon

Methamphetamine use is on the rise, with an imminent upsurge of abuse and dependence reported across the United States. Currently, preliminary evidence suggests that methamphetamine dependence may cause long-term neural damage in humans, with concomitant deleterious effects on cognitive processes such as memory and attention. This selective review provides an outline and synthesis of studies th...

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