Abstract Histopathological images are used to characterize complex phenotypes such as tumor stage. Our goal is associate features of stained tissue with high-dimensional genomic markers. We use convolutional autoencoders and sparse canonical correlation analysis (CCA) on paired histological bulk gene expression identify subsets genes whose levels in a sample correlate morphological from the cor...

Coordinated migration of newly born neurons to their prospective target laminae is a prerequisite for neural circuit assembly in the developing brain. The evolutionarily conserved LIS1/NDEL1 complex is essential for neuronal migration in the mammalian cerebral cortex. The cytoplasmic nature of LIS1 and NDEL1 proteins suggest that they regulate neuronal migration cell autonomously. Here, we exte...

objective:coriandrum sativum (c. sativum) as a medicinal plant has been pointed to have analgesic, hypnotic and anti-oxidant effects. in the current study, a possible preventive effect of the hydro-alcoholic extract of the plant on neuronal damages was examined in pentylenetetrazole (ptz) rat model of seizure.materials and methods: forty male rats were divided into five main groups and treated ...

abstract aim: to assess anti-neuronal antibodies (na) prevalence and their correlation with neurological disorders and bowel habits in celiac disease (cd) patients. background: neurological manifestations are estimated to occur in about 10% of celiac disease patients and na to central nervous system (cns) and enteric nervous system (ens) are found in a significant proportion of them. little is ...

Ewing sarcoma arises in both bones (most common) and soft tissues it commonly affects young adults. The tumor is composed of small round cells showing positivity for CD99 FLI1 on immunohistochemistry (IHC). We describe ganglion cell differentiation post-chemotherapy which a rare phenomenon. A 13-year-old girl presented with chest wall mass. On biopsy correlating IHC, the diagnosis was rendered ...

Stimuli to excitable cells and various cellular processes can cause cell surface deformations; for example, when membrane potentials are altered during action potentials. However, these changes may be at or below the diffraction limit (in dendrites structures measured as small 1 µm), imaging by traditional methods is challenging. Using dual lenses incoherent holography lattice light-sheet (IHLL...

transforming growth factor betas (tgf?s) are one of the most widespread and versatile cytokines. the three mammalian tgf? isoforms, ?1, ?2, and ?3, and their receptors regulate proliferation of neuronal precursors as well as survival and differentiation in neurons of developing and adult nervous system. functions of tgf?s has a wide spectrum ranging from regulating cell proliferation and differ...