Previously, we demonstrated that plasticity of frontal cortex is altered in aging rats: cholinergic lesions of the nucleus basalis magnocellularis (NBM) produce larger declines in dendritic morphology in frontal cortex of middle-aged and aged rats relative to young adults. To more closely examine the interactive effects of age and cholinergic deafferentation on synaptic connectivity in frontal ...

Porcine reproductive and respiratory syndrome (PRRS) is the most economically significant disease impacting pig production in North America, Europe, and Asia, causing reproductive losses such as increased rates of stillbirth and mummified piglets. The objective of this study was to explore the genetic basis of host response to the PRRS virus (PRRSV) in a commercial multiplier sow herd before an...

A lzheimer’s disease is a neurodegenerative disorder of the CNS characterized by deposition of neuritic plaques and neurofibrillary tangles with consequent neuron death. Clinically it is characterized by a progressive loss of memory and impairment of learning capacity (Selkoe 1997; Seabrook et al. 1999). Substance P (SP) is a neurotransmitter related to memory functions and learning properties,...

Magnocellular cholinergic neurons in the basal forebrain have long been recognized as vulnerable to the pathology of Alzheimer's disease. Despite numerous anatomical, pharmacological, behavioral, and physiological investigations of these neurons the cellular mechanism that underlines their selective vulnerability remains unclear. As part of an ongoing investigation into the molecular mechanism(...

background: alzheimer’s disease was known as a progressive neurodegenerative disorder in the elderly and is characterized by dementia and severe neuronal loss in the some regions of brain such as nucleus basalis magnocellularis. it plays an important role in the brain functions such as learning and memory. loss of cholinergic neurons of nucleus basalis magnocellularis by ibotenic acid can commo...

In this study, we describe our methods to automatically classify Twitter posts describing events of adverse drug reaction and medication intake. We developed classifiers using linear support vector machines (SVM) and Naïve Bayes Multinomial (NBM) models. We extracted features to develop our models and conducted experiments to examine their effectiveness as part of our participation in AMIA 2017...

The standard de nition of convergence of an in nite product of scalars is extended to the in nite product P= n=1Bn of k × k matrices; that is, P is convergent according to the de nition given here if and only if there is an integer N such that Bn is invertible for n¿N and P= limn→∞ m=NBm is invertible. A family of su cient conditions for this kind of convergence is given, along with examples sh...

Porcine reproductive and respiratory syndrome (PRRS) is the most economically significant disease impacting pig production in North America, Europe, and Asia, causing reproductive losses such as increased rates of stillbirth and mummified piglets. The objective of this study was to explore the genetic basis of host response to the PRRS virus (PRRSV) in a commercial multiplier sow herd before an...