Background: We investigated the effects of anthropometric, laboratory, and lifestyle factors on development non-alcoholic fatty liver disease (NAFLD) in a nationwide, population-based, 4-year retrospective cohort. Methods: The propensity score-matched study control groups contained 1,474 subjects who had data Korean National Health Insurance Service-National Sample Cohort 2009, 2011, 2013. NAFL...

Background: NAFLD is a clinical spectrum ranging from steatosis (fatty infiltration) to with inflammation, necrosis, fibrosis and cirrhosis resembling alcoholic hepatitis in the absence of abuse. The aim this work was determine early renal functional alterations overweight / obese children adolescents NAFLD, as assessed by estimated glomerular filtration rate using cystatin C, evaluate its rela...

BACKGROUND & AIMS Non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiovascular related death, particularly in those with hepatic fibrosis. We determined the prevalence of predicted fibrosis based on non-invasive fibrosis markers and the association of hepatic fibrosis with cardiovascular risk factors. METHODS Cross-sectional study of 575 Framingham Heart St...

BACKGROUND Nonalcoholic fatty liver disease (NAFLD) is the most frequent disease associated with abnormal liver tests that is characterized by a wide spectrum of liver damage, ranging from simple macro vesicular steatosis to steatohepatitis (NASH), cirrhosis or liver carcinoma. Liver biopsy is the most precise test to differentiate NASH from other stages of NAFLD, but it is an invasive and expe...

OBJECTIVE Nonalcoholic fatty liver disease (NAFLD) coexists with insulin resistance (IR), but it is uncertain whether NAFLD and IR contribute independently to atherosclerosis. We tested whether fatty liver, IR, and metabolic syndrome (MetS) features (waist, glucose, triglyceride, HDL cholesterol [HDL-C], and blood pressure) were associated with a marker of atherosclerosis (coronary artery calci...

Non-alcoholic fatty liver disease (NAFLD) is a common liver disease; the histological spectrum of which ranges from steatosis to steatohepatitis. Nonalcoholic steatohepatitis (NASH) often leads to cirrhosis and development of hepatocellular carcinoma. To better understand pathogenesis of NAFLD, we performed the pathway of distinction analysis (PoDA) on a genome-wide association study dataset of...

BACKGROUND To investigate the efficacy of different probiotic strains, their combinations and forms (alive or lyophilized) in nonalcoholic fatty liver disease (NAFLD) prevention. METHODS In this study, 70 rats have been used divided into 7 groups of 10 animals in each: I - intact rats, II-VII - rats with monosodium glutamate (MSG)-induced NAFLD. Rats with NAFLD were untreated (group II, MSG-o...

Background and Aim: MR Elastography (MRE) is a non-invasive gold standard to assess liver fibrosis in Non-Alcoholic Fatty Liver Disease (NAFLD). Porto-systemic collaterals (PsC) signify presence of clinically significant portal hypertension (CSPH) & associated with complications variceal hemorrhage, ascites overt encephalopathy. FibroScan shows low sensitivity specificity detect CSPH NAFLD, the...

BACKGROUND AND AIMS A new score for the histological severity of nonalcoholic fatty liver disease (NAFLD), called SAF (Steatosis, Activity and Fibrosis) has been developed. We aimed to evaluate the impact of this score on overall mortality. METHODS We used data from 139 patients with biopsy-proven NAFLD. All biopsies were graded according to the SAF scoring system and disease severity was cla...

INTRODUCTION Nonalcoholic fatty liver disease (NAFLD) can be seen as a manifestation of overnutrition. The muscle is a central player in the adaptation to energy overload, and there is an association between fatty-muscle and -liver. We aimed to correlate muscle morphology, mitochondrial function and insulin signaling with NAFLD severity in morbid obese patients. METHODS Liver and deltoid musc...