The neuropeptide galanin (Gal) and its receptors (GalR1, GalR2, and GalR3) are expressed in spinal cord. We have characterized the pharmacology of the antinociceptive effects of intrathecally (i.t.) administered galanin and its analogs in the formalin test in rats, using an automated flinch detection system. Intrathecal injection of rat galanin (Gal(1-29)) or human galanin (Gal(1-30)) produced ...

It has been reported that some agents which increase the concentration of catecholamines in brain potentiate morphine analgesia (3). It has also been reported that reserpine which depletes catecholamines from the brain and peripheral tissue antagonizes morphine analgesia (5). Since the role of catecholamines in morphine analgesia is a subject -of great interest, it was thought worthwhile to see...

It has been shown that stress and chronic pain could prevent the development of tolerance to morphine analgesia, which appears to be related to the activation of hypothalamus–pitutitary–adrenal (HPA) axis, activation of neuroendocrine systems and changes in neurochemical levels. Moreover, the involvement of nitric oxide (NO) in the development of tolerance to morphine analgesia has been implica...

It has been shown that stress and chronic pain could prevent the development of tolerance to morphine analgesia, which appears to be related to the activation of hypothalamus–pitutitary–adrenal (HPA) axis, activation of neuroendocrine systems and changes in neurochemical levels. Moreover, the involvement of nitric oxide (NO) in the development of tolerance to morphine analgesia has been implica...

Clinical observation of a synergistic effect of ketamine on morphine analgesia remains controversial. Although a pharmacodynamic basis for an interaction has been explored in animal and clinical studies, the possibility of a pharmacokinetic mechanism has not been investigated. Whereas both morphine and morphine-6-glucuronide are effective analgesics, morphine-3-glucuronide (M3G) lacks activity....

In traditional medicine,some of the plants have been used as analgesic effect of teucrium polium (TP) used traditionally to relieve headache,rheumatic arteritis and pain during pregnancy.for this purpost the perculated and suxheleted extracts of TP, with differnt doses,were injected intraperitonealy to the mice and the analgesic effect was determined by Tail Flick test(TF) and formalin test(FT)...

hanges in the concentration of either brain or blood glucose level appear to modulate antinociceptive and basal nociceptive processes. There are some contradictory data about the effect of diabetes on morphine antinociception. In this study the effects of alloxan-induced diabetes on morphine analgesia, tolerance and dependency were investigated, with a view to clarify the contradictions. Materi...

introduction: previously, we demonstrated that i.p. injection of aqueous extract prepared from aerial parts of drosera spatulata (droseraceae) can induced remarkable analgesia in both phases of formalin test in rats. because, analgesia induced in acute phase of formalin test mainly mediated by activation of central analgesic mechanisms and also paragigantocellularis (pgi) nucleus is part of bra...

there are controversial reports about the effect of captopril on pain modulation. also while captopril may potentiate morphine analgesia, enalapril has not such an effect and interaction of morphine with angiotensin ii receptor antagonists and other angiotensin converting enzyme inhibitors has not been studied yet. therefore, this study was designed to assess the effect of captopril, lisinopril...