Baclofen is the P-chlorophenyl derivative of gamma-aminobutyric acid (GABA) derivative with an antispasmodic action and is used as a central acting muscle relaxant. GABA is a suppressive neurotransmitter widely distributed in the peripheral and central nervous systems (1). Baclofen [3-(p-Chlorophenyl)4-aminobutanoic acid], is a GABA B agonist. Baclofen has both presynaptic and post synaptic act...

The existence of two classes of spermatogonial stem cells in the rat testis, i.e., reserve type A0 spermatogonia and renewing, types A1-A4 spermatogonia, postulated by Clermont and Bustos-Obregon ('68), was reexamined in a quantitative analysis of type A spermatogonia in both whole mounts of tubules and in radioautographed sections of testes from animals killed at various times, up to 26 days, ...

One of the natural examples to the power of concurrency is the ability to count to n with log n concurrent processes. In this work we study the cost of counting within weaker types of concurrency, where no cooperation takes place between the concurrent processes, except when time comes to decide whether the input should be accepted. We first study the number of states required for deterministic...

Microtubule-poisoning drugs, such as Paclitaxel (or Taxol, PTX), are powerful and commonly used anti-neoplastic agents for the treatment of several malignancies. PTX triggers cell death, mainly through a mitotic arrest following the activation of the spindle assembly checkpoint (SAC). Cells treated with PTX slowly slip from this mitotic block and die by mitotic catastrophe. However, cancer cell...

Based on the 2006 edition of the Model Size Metrics workshop, we believe that counts are undervalued as useful model metrics. In this position paper, we provide arguments from the literature so as to consider counts as important metrics for the model measurement. We then state associated issues and sketch a model-driven framework to raise the abstraction level of the implementation of model met...

In this current study, antiproliferative effect of Hec1/Nek2 Mitotic Pathway inhibitor INH1 was investigated in adenocarcinomic human alveolar basal epithelial cells A549 and cervix carcinoma HeLa cell lines vitro. To end index values by xCELLigence Real‐Time Cell Analysis DP instrument, mitotic index, BrdU proliferation assay apoptotic analysis were used. The results the study showed that had ...