High-performance polymers that have improved processing characteristics, and a method of making them, have been invented. One of the improved characteristics is low (relative to corresponding prior polymers) melt viscosities at given temperatures. This characteristic makes it possible to utilize such processes as resin-transfer molding and resin-film infusion and to perform autoclave processing...

Mitochondria play a key role in cellular signalling, metabolism and energetics. Proper architecture remodelling of the inner mitochondrial membrane are essential for efficient respiration, apoptosis quality control cell. Several protein complexes including contact site cristae organizing system (MICOS), F1FO-ATP synthase, Optic Atrophy 1 (OPA1), facilitate formation, maintenance stability membr...

New aromatic glycoconjugate building blocks based on the trifunctional 3-aminomethyl-5-aminobenzoic acid backbone and sugars linked to the backbone by a malonyl moiety were prepared via peptide coupling. The orthogonally protected glycoconjugates, bearing an acetyl-protected glycoside, were converted into their corresponding acids which are suitable building blocks for combinatorial glycopeptid...

mitochondrial respiration is a complex process which its biochemistry is often poorly understood by undergraduate students when explained in toxicology lectures. the use of experiments to reinforce their knowledge is important, but not always possible because of low teaching budgets. therefore, a low cost model, made using water, oil, styrofoam and modeling clay, is presented here to simulate t...

skin aging is a continuous process that exhibits fine and deep wrinkles, thin and transparent skin, loss of underlying fat, dry skin and itch, following decreased collagen and elastin  synthesis. both extrinsic and intrinsic agents are considered in the pathogenesis on skin aging. extrinsic factors such as sun exposure, windy and dry weather, nutrition, and lifestyle may induce premature aging,...

Friedreich's ataxia (FRDA) is an inherited, neurodegenerative disease that typically presents in childhood and results progressive gait limb ataxia, with the extraneural features of hypertrophic cardiomyopathy, diabetes scoliosis. The genetic defect a deficiency frataxin protein, which important for mitochondrial function, especially brain heart. Drug development has approached FRDA through pat...

aim : the aim of this study was to evaluate and compare three available methods for mitochondrial isolation from a human cell line to predict the best method for each probable application.   background : organelle isolation is gaining importance in experimental laboratory settings. mitochondrial dysfunction may affect tumorgenesis process. there are some evidences that transplantation of health...

Defects in mitochondrial function activate compensatory responses the cell. Mitochondrial stress that is caused by unfolded proteins inside organelle induces a transcriptional response (termed “mitochondrial protein response” [UPRmt]) mediated activating transcription factor associated with 1 (ATFS-1). The UPRmt increases quality control. dysfunction frequently causes defects import of proteins...

Novel biodegradable poly(amino ester)s containing secondary and tertiary amines in the backbones were obtained from the Michael addition polymerizations of trifunctional amine monomers with diacrylates, and showed high transfection efficiency for the delivery of DNA comparable to those of polyethylenimine (PEI) and low cytotoxicity.