Abstract Background The incidence of obesity is increasing worldwide, and it a risk factor for diabetes, dyslipidemia, nonalcoholic fatty liver disease. Our previous study had demonstrated that high-fat diet induced increased weight gain, fat weight, serum cholesterol, triglyceride, ATL levels in liver, influenced the diversity composition cecal microbiota mice. Hence, this aimed to investigate...

Background & Aim: Cutaneous infection caused by protozoa the genus Leishmania are a major worldwide health problem, with high endemicity in developing countries including Middle East, Africa and Latin America. In the absence of a vaccine, there is an urgent need for effective drugs to replace and supplement those in current use. Experimental: In this study, the in vivo effica...

This research is to evaluate the acute and subchronic toxicities of “Kien ty chi thong - HV” granules through oral administration in experimental animals. The toxicity was determined by Litchfield Wilcoxon method Swiss mice. evaluated WHO OECD’s recommendation Wistar rats with doses 1.8 g/kg/day (equal recommended human dose) 5.4 (3 times as high 4 consecutive weeks. As a result, at highest dos...

Abstract Forkhead transcription factor (FoxO) plays key roles in the induction of various downstream genes involved inhibition cellular metabolism, cell death, cycle, and oxidative stress responses. FoxO6 is expressed liver, skeletal muscle, hippocampus brain. also has been proposed to play a role promotion insulin resistance, inflammation. In this study, we tried determine neuroinflammation in...

The prevalence of nonalcoholic fatty liver disease (NAFLD) has been rapidly increasing worldwide. A choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD) used to create a mouse model steatohepatitis (NASH). There are some reports on the effects mice being fed CDAHFD for long periods 1 3 months. However, effect this over short period is unknown. Therefore, we examined 1-week feeding li...

The aim of this study was to evaluate the antioxidant activity exopolysaccharides (EPS) from Lactobacillus kimchi SR8. EPS exhibited strong scavenging activities for 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radicals. Two fractions (EPS-1 EPS-3) higher than EPS-2. Low-dose CEPS could significantly increase catalase (CAT) glutathione peroxidase (GSH-Px) in serum CAT, GSH-Px superoxide dismutase...

PURPOSE Since deterioration of the immune apparatus is closely associated with cancer, we examined the effect of aging on the growth and metastasis of intraocular melanomas in mice. METHODS Murine B16LS9 melanoma cells were transplanted into the posterior compartment of the eye (vitreous chamber) and intraocular tumor growth and development of liver metastases were evaluated in young (8-10 we...

Abstract Background Hepatocellular carcinoma (HCC) is the leading cause of death worldwide. Nanoparticles allow early detection tumor and delivery chemotherapeutic drugs to specific site. This study aimed assess therapeutic role dumbbell-like nanoparticles conjugated with monoclonal antibodies (mAbs) against both vascular endothelial growth factor (VEGF) cluster differentiation (CD) 90 (a cance...

Liver regeneration is a fundamental mechanism by which the liver responds to injury. This process is regulated by endogenous growth factors and cytokines, and it involves proliferation of all mature cells that exist within the intact organ. To understand the role of the GH/IGF-I axis in liver regeneration, we performed partial hepatectomies in three groups of mice: GH antagonist (GHa) transgeni...