Objective(s): Metformin (Met), an antidiabetic biguanide, reduces hyperglycemia via improving glucose utilization and reducing the gluconeogenesis. Met has been shown to exert neuroprotective, antioxidant and anti-inflammatory properties. The present study investigated the possible effect of Met on the D-galactose (D-gal)-induced aging in mice. Materials and Methods: Met (1 and 10 mg/kg/p.o.), ...

Background and Aim: Prolonged stress causes deleterious effects on both the organism its microbiota. In this study, we examined of exposure to variable frequency ultrasound (US) gut microbiota-liver-brain axis mice. Materials Methods: This study was conducted 20 mature clinically healthy sexually naive C57BL/6J male mice (42–45 days old). Group 1 (Normal) consisted intact (n = 10). 2 (Stress) s...

Considerable evidence suggests that insulin resistance is closely linked to Parkinson's disease (PD), leading agents aiming at treating diabetes can be regarded as new neuroprotective strategies in PD, notably glucagon-like peptide-1 (GLP-1). However, the extremely short half-life of GLP-1 due degradation by ubiquitous proteolytic enzyme limits its clinical application. In this study, we engine...

Abstract The aim of the current study was to evaluate therapeutic potentials Hydroxyquinoline Sulfanilamide (HSM) for Alzheimer’s disease in a mice model Streptozotocin (STZ)-induced diabetes. antioxidant analysis brain homogenates carried out by catalase (CAT) assay, reduced glutathione (GSH) and lipid peroxidation (LPO) assay. Biochemical blood plasma conducted peroxidase (POD) assay superoxi...

Background: Parkinson’s disease (PD) is one of the most common degenerative disorders ageing brain. Currently, there no cure for PD and available treatments only aim to reverse dopamine deficiency relieve its symptoms. Caloric vestibular stimulation (CVS) believed help in relieving motor symptoms PD. Hence, present study planned evaluate effect CVS on behavioral changes Mice. Methods: Twenty-fo...

background: to compare the pathogenicity differences in two susceptible balb/c and resistant c57bl/6 mice infected with leishmania major mrho/ir/75/er as a prevalent strain of zoonotic cutaneous leishmaniasis in iran. methods : mice were assigned into four groups as control and infected balb/c and c57bl/6 mice. experimental leishma­niasis was initiated by (s. c) injection of the 2×10 6 l. major...

Abstract Introduction Preclinical evidence has identified the trace amine-associated receptor 1 (TAAR1) as a novel regulator of metabolic control. Ulotaront is TAAR1 and 5-HT 1A agonist currently in Phase 3 clinical trials for treatment schizophrenia. Here we summarize preclinical results assessing effects ulotaront on weight parameters. Methods Effects administration were evaluated oral glucos...

While it is well established that the isoform 2 of hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN2) plays an important role in development and maintenance pain, closely related HCN4 processing nociceptive signals not known. channels are highly expressed thalamus, a region for stimulus transmission information processing. We used brain-specific HCN4-knockout mouse line (...

objective(s) the possible risks of radio-frequency electromagnetic fields (emf) for the living organisms and human body are a growing concern for our society. in this study, we examined the possibility of changes in working memory and hippocampal histological characteristics effects in mice brain following whole body exposure to microwave radiation. materials and methods during gestation period...