نتایج جستجو برای: melanocytic skin cancer
تعداد نتایج: 1085050 فیلتر نتایج به سال:
BACKGROUND Skin cancer is the most common type of cancer. Of the 4 million skin lesions excised annually worldwide, approximately 2 million are considered cancerous. In this study, we aimed to describe a regional experience with skin cancers treated by a single senior surgeon and to provide a treatment algorithm. METHODS The medical records of 176 patients with head and neck non-melanocytic s...
Background Collision lesions as two independent and unrelated skin tumors often manifest an atypical morphology. Objective To determine the combinations of collision skin lesions (CSLs). Methods Twenty-one pigmented lesion clinics in nine countries included 77 histopathologically proven CSLs in this retrospective observational study. Results Seventy-seven CSLs from 75 patients (median age...
A decrease in the level of the ROC1 protein, which is involved in cyclin D1 degradation, might explain an increase in cyclin D1 protein in the absence of gene overexpression. This study aimed to investigate the relationship between ROC1 and cyclin D1 expression in skin melanomas. A total of 62 cases of primary skin melanomas and 58 cases of compound melanocytic nevi were assessed. Immunohistoch...
BACKGROUND Reported data indicate that cancer cells have increased rates of glucose metabolism, as determined by 18FDG-PET imaging in patients with malignancies. The results of many studies have demonstrated that the expression of glucose transporters, especially Glut-1, is increased in a variety of malignancies. This study was undertaken to assess the differential expression of Glut-1 and Glut...
Relatively little is known about clinical and epidemiologic characteristics of nevi melanoma in skin color minorities (SOCM) compared to Caucasians. We conducted a prospective study between 3/2017-8/2018 211 patients that volunteered for cancer screening examination. The distribution melanocytic neoplasms was recorded. Surveillance, Epidemiology, End Results Program (SEER) data used identify fr...
background & objectives: in the 6-billion-population world 2000, approximately 10 million cancers were diagnosed, among which there were an estimated 6.2 million cancer deaths. whereas the universality of cancer incidence and mortality is established, the burden of cancer by type or organ site is distributed unequally between developing and industrialized nations. we want to collect some inform...
Melanocytic nevi are benign melanocyte proliferations. They are well demarcated macula or papilla that may have the same color with the skin or may have reddish-brown, brown, or black color. Melanocytic nevi may be congenital or acquired. In white race, almost every individual have approximately 20 nevi on average (1). In a typical life cycle melanocytic nevi develop after infancy, reach a peak...
BACKGROUND Multiple congenital melanocytic naevi (CMN) in one individual are caused by somatic mosaicism for NRAS mutations; however, the lineage of the mutated cells remains uncertain. OBJECTIVES To test the hypothesis that CMN may be derived from cutaneous stem cells. METHODS Sixty-six CMN samples from 44 patients were stained for immunohistochemical (IHC) markers of melanocytic different...
Recent reports suggested frequent occurrence of cancer associated somatic mutations within regulatory elements of the genome. Based on initial exome sequencing of 21 melanomas, we report frequent somatic mutations in skin cancers in a bidirectional promoter of diphthamide biosynthesis 3 (DPH3) and oxidoreductase NAD-binding domain containing 1 (OXNAD1) genes. The UV-signature mutations occurred...
IMPORTANCE Cutaneous metastases rarely develop in patients with cancer but have important implications for prognosis and treatment. While dermoscopy is useful for many skin lesions, few data exist regarding dermoscopic findings in cutaneous metastases. OBSERVATIONS We reviewed high-quality dermoscopic images of 20 outpatients with biopsy-proven cutaneous metastases and known diagnosis of unde...
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