OBJECTIVE To test the Mayo Clinic Quadratic (MCQ) equation against isotopic glomerular filtration rate, compared with the Modification of Diet in Renal Disease (MDRD) and the Cockcroft-Gault formulas, in type 2 diabetes. RESEARCH DESIGN AND METHODS Based on values obtained with iothalamate, 118 type 2 diabetic patients were divided into three groups according to renal function: hyperfiltratio...

The aim of this study was to develop a population-pharmacokinetic model of ceftazidime in intensive care unit patients to include the influence of patients' characteristics on the pharmacokinetics. Forty-nine patients for model building and 23 patients for validation were included in a randomized study. They received ceftazidime at 2 g three times a day or as 6 g per day continuously. A NONMEM ...

Objective: It’s recommended to use equations such as Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Epidemiology Collaboration (CKD-EPI) by using creatinine level estimating glomerular filtration rate (GFR). Here, we aimed compare serum cystatin-C (Cys-C) Cys-C based with patients chronic kidney disease (CKD) nephrotic syndrome (NS).

CONTEXT The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation more accurately estimates glomerular filtration rate (GFR) than the Modification of Diet in Renal Disease (MDRD) Study equation using the same variables, especially at higher GFR, but definitive evidence of its risk implications in diverse settings is lacking. OBJECTIVE To evaluate risk implications of estimated ...

BackgroundNon-Vitamin K Oral Anticoagulants (NOACs) are used for prevention of thromboembolism in patients with atrial fibrillation (AF). Guidelines recommend dose adjustment based on kidney function.The most common estimates function employed clinical practice derived from glomerular filtration rate (eGFR), however, product monographs the use Cockcroft-Gault creatinine clearance equation (eCrC...

The introduction of estimated GFR (eGFR) reporting based on the Modification of Diet in Renal Disease (MDRD) equation has caused much debate regarding its value in the wider community. In particular, automated reporting of eGFR by laboratories has led to concern that it is being used as a "covert " screening tool, in populations in which the MDRD equation has known inaccuracies. There is a fear...

Stevens et al suggest that the Modification of Diet in Renal Disease (MDRD) Study equation for estimated glomerular filtration rate (GFR) is an acceptable substitute for estimated or measured creatinine clearance (CCr) as an index for adjusting drug doses in patients with chronic kidney disease and acute kidney injury. However, others have raised concerns that injudicious use of estimated GFR a...

We present a case of IgA nephropathy (IgAN) in monozygotic twins with excellent donor and recipient outcome 11 years after transplantation. The recipient developed IgAN at 26 years and progressed to end-stage renal failure 10 years later. His identical twin who had hypertension, intermittent microscopic haematuria and positive IgA immunofluorescence on biopsy became his donor. Eleven years foll...

Regarding the prevalence of chronic kidney disease in the population, estimation of glomerular filtration rate is of importance. Creatinine-based formulas are thus useful as the first step of a prevention strategy. Several creatinine-based formulas have been published. Among these, the Cockcroft-Gault formula and the Modification of Diet in Renal Disease (MDRD) study equation are the most used ...