The variety of factors controlling the onset of parturition, äs well äs the very complex mechanisms which physiologically maintain pregnancy by inhibiting uterine contractions are only partially understood today. As long äs the triggering mechanisms, and the conditions favoring timely and early labor are incompletely known, symptomatic therapeutic attempts aim at blocking unwanted contractile a...

Purpose Maintenance therapy is an effective treatment strategy for advanced non-small-cell lung cancer (NSCLC). We aim to investigate whether age would affect the efficacy of maintenance therapy in the treatment of advanced NSCLC. Materials and methods Relevant trials were identified by searching electronic databases and conference meetings. Prospective randomized controlled trials assessing ...

The MM-015 trial assessed the effect of lenalidomide-based therapy on health-related quality of life. Patients (n=459) with newly diagnosed multiple myeloma aged 65 years or over were randomized 1:1:1 to nine 4-week cycles of lenalidomide, melphalan, and prednisone, followed by lenalidomide maintenance; or lenalidomide, melphalan, and prednisone, or melphalan and prednisone, with no maintenance...

OBJECTIVES The aim of this study was to determine if the actions of progesterone on preterm labor are accomplished through modulation of the percentage of regulatory T-cells (Treg). METHODS The study was a cohort pilot study made in a single center tertiary obstetrical unit with women in preterm labor arrested with tocolytic treatment. Variation of the number and percentage of Treg cells obta...

BACKGROUND Progesterone may be effective in prevention of premature birth in some high risk populations. Women with arrested premature labor are at risk of recurrent labor and maintenance therapy with standard tocolytics has not been successful. METHODS Randomized double blinded clinical trial of daily treatment with 200 mg vaginal progesterone in women with arrested premature labor and an up...

Neonatal purpura fulminans is a rare and life threatening disease that can be inherited or acquired in etiology. It manifests as DIC and extensive subcutaneous thrombosis. The condition is often fatal unless there is prompt diagnosis, and judicious therapy. The most important causes of this condition are infections and congenital deficiency of anticoagulant proteins C and S.In the case of PC (p...

Comparison of the Effectiveness Acceptance and Commitment Therapy, Mindfulness, Motivational Interviewing on Intentional Self-Regulation in Individuals with Substance Use Disorder under Maintenance Therapy

One of the most established roles of oxytocin (OT) is in inducing uterine contractions and labor. Apart from inducing contractions, our recent studies showed that OT can also activate proinflammatory pathways in both human myometrial and amnion cells, which suggests that the proinflammatory role of OT should be taken into account when developing tocolytics targeting the OT/oxytocin receptor (OT...

results results showed that there was a significant difference between the experimental and control groups in terms of depression and temping beliefs (p < 0.0001). in other words, the results showed that cognitive-behavior therapy reduces depression and improves craving beliefs of abusers under methadone maintenance treatment. objectives this study aimed at investigating the effectiveness of co...