Current cancer diagnosis procedure requires expert knowledge and is time-consuming, which raises the need to build an accurate support system for lymphoma identification classification. Many studies have shown promising results using Machine Learning and, recently, Deep detect malignancy in cells. However, diversity complexity of morphological structure make it a challenging classification prob...

STATs are constitutively activated in several malignancies. In primary mediastinal large B-cell lymphoma and Hodgkin lymphoma (HL), inactivating mutations in SOCS1, an inhibitor of JAK/STAT signaling, contribute to deregulated STAT activity. Based on indications that the SOCS1 mutations are caused by the B cell-specific somatic hypermutation (SHM) process, we analyzed B-cell non-HL and normal B...

Involvement of the ovary by malignant lymphoma is well known as late manifestation disseminated disease. Primary ovarian lymphoma(POL) extremely rare , accounting for 0.5 % all NHLs and 1.5% neoplasms1 . We here in describe a case Large B cell Lymphoma involving bilateral ovaries 34 year old female.Preoperative CT imaging showed heterogenous soft tissue masses with cystic areas both ovaries. Sh...

Diffuse large B-cell lymphoma (DLBCL) of the heart accounts for only 1% primary cardiac tumors. Histopathologic examination becomes key diagnosis and immunohistochemical evaluation non-Hodgkin (NHL) subtype determination is able to predict disease progression therapeutical modality. Case description: 70-year-old man complained shortness breath. Echocardiographic revealed mass occupied left atri...

According to the World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues, diffuse large B-cell lymphoma comprises about 40% of adult cases of non-Hodgkin s lymphoma. It consists of the following morphological variants: 1) centroblastic (with or without multilobulated nuclei); 2) immunoblastic (>90% of immunoblasts); 3) T cell/histiocytes rich; a...

Tumor necrosis factor-α-inducible protein-2 (TNFAIP2) is a protein upregulated in cultured cells treated with tumor necrosis factor α (TNF), but its expression in normal and neoplastic tissues remains largely unknown. Here, we use standard immunohistochemical techniques to demonstrate that TNFAIP2 is normally expressed by follicular dendritic cells, interdigitating dendritic cells, and macropha...

Purpose: To describe the long-term outcomes of 2 cases primary autologous stem cell transplantation (ASCT) for treatment central nervous system lymphoma–ophthalmic variant (PCNSL-O) or vitreoretinal lymphoma (PVRL). Methods: Two and their findings were analyzed. A review histopathology, systemic treatment, multimodal ocular imaging was performed. Results: 52-year-old woman 56-year-old referred ...

primary colorectal lymphoma (pcl) is a rare condition that accounts for a small percentage of all gastrointestinal (gi) malignancies. there are several reports in the literature regarding the most common features of pcl. however, primary lymphoma in the rectosigmoid junction has been rarely reported. our case was a 67-year-old male who presented with non-specific symptoms of bowel obstruction w...