conclusions cardiovascular risk factors were higher in subjects with diabetes compared to subjects without diabetes. lifestyle intervention programs should be focused on community education about reduction of cvd risk factors in patients with diabetes. background cardiovascular disease (cvd) is developing treacherously along industrialization and development of urbanization objectives the aim o...

results cloning was confirmed by pcr and restriction digestion. rt-pcr and sds-page represented expression of kgf in e. coli. the optimized expression was achieved 16 hours after induction with 0.3 mm iptg at 37°c in luria broth (lb) containing kanamycin. the 18 kda protein was confirmed by western blotting, using anti-his antibodies. conclusions the result of the present study indicated that e...

background: impact of high level of uric acid on stroke is still controversial. we conducted this study to investigate the relationship between acute ischemic non-embolic stroke and serum levels of uric acid. methods: this was a case-control study on patients with acute ischemic non-embolic stroke in rafsanjan, iran. the control group consisted of normal persons who were similar to the case gro...

thrombophilia increases the incidence of pulmonary thrombosis significantly. various hereditary and acquired factors are known for thromboembolism. the hereditary factors are two common genetic autosomal mutations including factor v leidan mutation and prothrombin gene mutation. a descriptive- analytical design was conducted on 60 patients with thromboembolism who met the inclusion criteria. tw...

low glucose condition induces neuronal cell-death via intracellular mechanisms including mitogen-activated protein kinases (mapk) signaling pathways. it has been shown that low glucose medium decreases neuronal survival in cerebellar granule neurons (cgns). in this study, we have examined the activation of jnk, p38kinase and erk1/2 pathways in low glucose medium in cgns. the cgns were prepared ...

background and objective: to assess the incidence and risk factors of upper gastrointestinal bleeding in children admitted to pediatric intensive care unit for more than 6 hrs. methods: we prospectively collected medical records of children between 1 month and 18 years old admit-ted to our 10 bed picu of a tertiary care university hospital between december 1, 2014 and may 30, 2015. de-mographic...

background and purpose: brain-derived neurotrophic factor (bdnf) is present in the hippocampus and cerebral cortex in high concentrations and has an important role in development, maintenance and regeneration of the nervous system. the aim of this study was to produce active bdnf in e.coli using transforming plasmid. methods: to construct an expression plasmid of bdnf, a gene coding for it was ...

factor v (fv) deficiency is a rare bleeding disorder (rbd) that inherit in autosomal recessive manner. diagnosis of fv deficiency (fvd) is made by routine coagulation tests, fv activity and molecular analysis. in patients with fvd, routine coagulation tests including activated partial thromboplastin time (aptt), prothrombin time (pt) and evenbleeding time (bt) are prolongedwhile thrombin time (...

background: several environmental and psychosocial risk factors are known for adolescent smoking as the single cause of preventable diseases and premature death. this cross-sectional study aimed to determine the prevalence of cigarette smoking, socio-demographic factors associated with cigarette smoking (age, education level, parents’ job, and family’s socioeconomic statues), and the role of fa...

background: single-nucleotide polymorphism (snp) rs2476601 within protein tyrosine phosphatase non-receptor type 22 gene (ptpn22) has been shown to be a risk factor for different autoimmune diseases. this study explored the association of 1858 c/t snp with rheumatoid arthritis (ra) and celiac disease (cd) in a region covering south-west of iran. methods: totally, 52 patients with cd, 120 patien...