1,3-Alternate cationic calix[4]arene proved highly selective for proton/halogens symport transport and showed antiproliferative activity against murine monocyte/macrophage J774.A1 cancer cells.

the carrier facilitated transport of lithium picrate was studied using a series of non-cyclic polyethers containing different end groups and chain lengths through bulk liquid membrane (blm) and supported liquid membrane (slm) systems. the various membrane supports used are viz. ptfe, cellulose nitrate, and dialysis membrane and onion membrane. the amount of li+ transported depends upon the stru...

The functional group-containing potassium ionophore 19(5),24(5)-dibromo-4,7,13,16,20,23-hexaoxa-1,10-diaza-19(1,2),24(1,2)-dibenzabicyclo[8.8.6]tetracosaphane has been synthesized.

A series of non-cyclic polyethers with different end groups and chain length were used for the extraction of lithium salt from aqueous into various organic phases viz. Chloroform, Carbon tetrachloride, 1,2-dichloroethane, to study the influence of structural variations within the extractant molecule upon the extraction selectivity and efficiency. The ionophores used were viz. DEG (I), DEGDME (I...

The efficacy of three polyether ionophores viz. salinomycin, monensin and maduramicin was evaluated in poultry. Dayold chicks (n=350) were randomly divided into seven groups of 50 chicks each. The drugs were administered as feed premix from day one onwards. The chicks at 14-day of age were initially infected with 20,000 sporulated viable oocysts of Eimeria tenella and challenged with 40,000 spo...

The activation of defense genes in response to wounding involves the integration of multiple inputs from various signaling molecules produced in different tissues and cellular compartments. In this report, we demonstrate that calcium and magnesium ions enhance systemin activity and that calcium fluxes are necessary for wound gene activation. During wounding, intracellular contents such as calci...

A microsomal fraction resembling striated muscle sarcoplasmic reticulum was isolated from uterine smooth muscle. ATP induces calcium accumulation in this fraction. Increased temperature enhances calcium accumulation and calcium-activated ATPase. In the absence of ATP, approximately 35% of the intrinsic calcium exchanges with the 45Ca in the incubation medium. In the presence of ATP, exchange of...

Beef cattle have been fed ionophores and other antibiotics for more than 20 years to decrease ruminal fermentation losses (e.g methane and ammonia) and increase feed efficiency, and these improvements have been explained by an inhibition of gram-positive ruminal bacteria. Ionophores are not used to treat human disease, but there has been an increased perception that antibiotics should not be us...

Antibiotics can improve ruminant growth and efficiency by altering rumen fermentation via selective inhibition of microorganisms. However, antibiotic use is increasingly restricted due to concerns about the spread of antibiotic-resistance. Plant-based antimicrobials are alternatives to antibiotics in animal production. The hops plant (Humulus lupulus L.) produces a range of bioactive secondary ...

Earlier studies have shown that the intracellular killing of Staphylococcus aureus by human monocytes requires continuous stimulation by serum factors, e.g., immunoglobulin G (IgG). In the present study, we demonstrate that IgG, at concentrations that stimulate the intracellular killing of S. aureus, induces a transient increase in the intracellular free calcium concentration ([Ca2+]i) in monoc...