Downlo ptive response (AR) is a term describing resistance to ionizing radiation–induced killing or formation of nt chromosomes that is mediated by pre-exposure to low ionizing radiation doses. The mechanism of ains elusive. Because cell killing and chromosome aberration formation derive from erroneous procesf DNA double-strand breaks (DSB), AR may reflect a modulation of DSB processing by nonh...

Do you have moles on face? Are the moles good or bad? We could treat this problem from medical, cosmetic, or even fortune applications viewpoint. Here, image processing techniques are investigated to detect and verify the goodness of face mole from fortune telling point of view. The process includes Voronoi diagram setup for sample moles, face mole detection, and mole recognition. In the first ...

Download wth factors and many oncogenes activate the lipid kinase phosphoinositide 3-kinase (PI3K), ing a signaling cascade that includes the protein kinases AKT and target of rapamycin (TOR). The AKT/TOR signaling pathway is a significant contributor to disease in various human cancers, includmatologic malignancies. Here we discuss different strategies to inhibit TOR for the treatment of ia, l...

African mole-rats (family Bathyergidae) are small to medium sized, long-lived, and strictly subterranean rodents that became valuable animal models as a result of their longevity and diversity in social organization. The formation and integration of new hippocampal neurons in adult mammals (adult hippocampal neurogenesis, AHN) correlates negatively with age and positively with habitat complexit...

The abnormal pregnancies complete and partial hydatidiform mole are genetically unusual, being associated with two copies of the paternal genome. Typical moles (CHMs) diploid androgenetic, while (PHMs) diandric triploids. While diagnosis can usually be made on basis morphology, ancillary techniques that exploit their unusual genetic origin used to facilitate diagnosis. Genotyping p57 immunostai...

The distribution of orexinergic cell bodies and terminal networks within the brains of two species of African mole rat (Cape-dune mole rat--Bathyergus suillus and highveld mole rat--Cryptomys hottentotus) were identified using immunohistochemistry for orexin-A. The aim of the study was to investigate possible differences in the nuclear complement and terminal distribution of this system by comp...

Downlo inhibitors are under clinical investigation, specifically in patients with tumor types harboring frequent ting mutations in B-Raf. Here, we show that cell lines and tumors harboring mutant B-Raf were sento a novel series of Raf inhibitors (e.g., B-Raf A375, IC50 on cells = 2 nmol/L; ED50 on tumor rafts = 1.3 mg/kg). However, in cells and tumors with wild-type B-Raf, exposure to Raf inhib...

Partial or complete mole affects one in 1000  pregnancies.Partial mole is a rare form of ectopic pregnancy. There was a married woman,gravid 4,parity 1,abortion 1,and she had past medical history 0f right ectopic pregnancy.she had left ectopic pregnancy and was treated by laparascopic left salpyngectomy after failure of intramascular methotrexate treatment.After surgery  the pathology exam show...

OBJECTIVES To determine epidemiological characteristics and clinical presentation of complete hydatidiform mole (CHM) and complications associated with prophylactic chemotherapy with oral methotrexate. SETTING Mulago hospital, Kampala. DESIGN Prospective study. METHODS Ninety-four patients with clinically and histologically confirmed complete hydatidiform mole admitted between 1/9/1995 an...