نتایج جستجو برای: intercalator
تعداد نتایج: 371 فیلتر نتایج به سال:
The crystal structure of a daunomycin-d(CGTACG) complex has been solved by X-ray diffraction analysis and refined to a final R factor of 0.175 at 1.2-A resolution. The crystals are in a tetragonal crystal system with space group P4(1)2(1)2 and cell dimensions of a = b = 27.86 A and c = 52.72 A. The self-complementary DNA forms a six base pair right-handed double helix with two daunomycin molecu...
Indenoisoquinolines are topoisomerase I (Top1) inhibitors developed to overcome some of the limitations of camptothecins and expand their anticancer spectrum. NSC 727357 is a novel dimeric indenoisoquinoline derivative with potent antiproliferative activity in the NCI-60 cell line panel, promising hollow fiber activity (score = 32) and activity against xenografts. Submicromolar concentrations o...
The combination of DNA force spectroscopy and polarization microscopy fluorescent intercalator dyes can provide valuable insights into the structure under tension. These techniques have previously been used to characterize S-DNA—an elongated conformation that forms when overstretches at forces ? 65 pN. In this way, it was deduced base pairs S-DNA are highly inclined, relative those in relaxed (...
Efficient DNA intercalators comprising naphthalene diimide grafted with ethylenedioxythiophene monomer were successfully designed, synthesized and applied to mediate/promote conducting polymer growth electrochemically on biosensor electrodes for direct and amplified DNA detection.
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