Recent theories posit that adult neurogenesis supports dentate gyrus pattern separation and hence is necessary for some types of discrimination learning. Using an inducible transgenic mouse model, we investigated the contribution of adult-born neurons to spatial and nonspatial touch-screen discriminations of varying levels of difficulty. Arresting neurogenesis caused a modest but statistically ...

BACKGROUND Although echocardiography is commonly performed before coronary artery bypass surgery, there has yet to be a study examining the incremental prognostic value of a complete echocardiogram. METHODS AND RESULTS Patients undergoing isolated coronary artery bypass surgery at 2 hospitals were divided into derivation and validation cohorts. A panel of quantitative echocardiographic parame...

BACKGROUND The prevalence of diabetes is increasing in all industrialized countries and its prevention has become a public health priority. However, the predictors of diabetes risk are insufficiently understood. We evaluated, whether 31 novel biomarkers could help to predict the risk of incident diabetes. METHODS AND FINDINGS The biomarkers were evaluated primarily in the FINRISK97 cohort (n ...

OBJECTIVE The present study aims to investigate whether the addition of homocysteine level to the Global Registry of Acute Coronary Events (GRACE) risk score enhances its predictive value for clinical outcomes in ST-elevation myocardial infarction (STEMI). METHODS A total of 1143 consecutive patients with STEMI were included in this prospective cohort study. Homocysteine was detected, and the...

Nowadays, in highly competitive global markets and constant pressure to reduce total costs, enterprises consider group technology and Supply Chain Management (SCM) accordingly and usually separately as the key elements for intra and inter facilities improvement. Simultaneous consideration of the elements of these two disciplines in an integrated design can result in higher efficiency and ...

BACKGROUND It remained unclear whether the combination of the Canada Acute Coronary Syndrome Risk Score (CACS-RS) and N-terminal pro-brain natriuretic peptide (NT-pro-BNP) could have a better performance in predicting clinical outcomes in acute ST-elevation myocardial infarction (STEMI) patients with primary percutaneous coronary intervention. METHODS A total of 589 consecutive STEMI patients...

Racial discrimination is conceptualized as a psychosocial stressor that has negative implications for mental health. However, factors related to racial identity may influence whether negative experiences are interpreted as instances of racial discrimination and subsequently reported as such in survey instruments, particularly given the ambiguous nature of contemporary racism. Along these lines,...

We extend the study of the performance of a prototype two-phase liquid xenon WIMP dark matter detector to energies below 20 keV. We demonstrate a new method for obtaining the best estimate of the energy from events, show that fluctuations in recombination limit discrimination for most energies, and reveal a surprising improvement in discrimination below 20 keV, which is crucial for a high-sensi...

Textbooks present the three ‘degrees’ of price discrimination as a sequence of independent pricing methods. These textbook treatments consequently provide inadequate insight as to when a firm might adopt a particular pricing strategy. The paper describes an informationbased taxonomy of price discrimination, which can be used to teach monopolistic price discrimination in an integrated way. The p...

Rabbits were trained to discriminate patterns consisting of straight bars and rows of dots of different orientation. It was found that using proximal pattern presentation, at a distance of 5 cm in front of the animal, dot rows of different orientation are not discriminated on the basis of tilt extrapolation, but by the use of regional cues.